ArticleProceedings of the National Academy of Sciences of the United States of America2021
Interaction between the type 4 pili machinery and a diguanylate cyclase fine-tune c-di-GMP levels during early biofilm formation.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed, 53 citations in OpenAlex.
- Review
- Co-Expression of PA0290 and PelD EnhancesMicroorganisms · 2026Article
- Insight into the relationship between type IV pilus function and biofilm formation.Biochemical Society transactions · 2026Review
- Defining the role ofJournal of bacteriology · 2026Article
- Role of Tad pili during the transition from planktonic to biofilm state inJournal of bacteriology · 2026Article
- Elasticity promotes directional transport ofSoft matter · 2026Article
- UnderstandingMicroorganisms · 2026Review
- Sewer biofilms as drivers of greenhouse gas emissions in urban sewer systems: mechanisms and control strategies.Frontiers in microbiology · 2026Review
- Separation ofmBio · 2025Article
- Twitching motility suppressors reveal a role for FimX in type IV pilus extension dynamics.PLoS genetics · 2025Article
- Article
- Genetic analysis of flagellar-mediated surface sensing byJournal of bacteriology · 2025Article
- Review
- c-di-GMP phosphodiesterase ProE interacts with quorum sensing protein PqsE to promote pyocyanin production inmSphere · 2025Article
- Morphogenesis of bacterial cables in polymeric environments.Science advances · 2025Article
- Anti-Biofilm Agents to OvercomePharmaceuticals (Basel, Switzerland) · 2025Review
- Building permits-control of type IV pilus assembly by PilB and its cofactors.Journal of bacteriology · 2024Review
- Cyclic Diguanylate in the Wild: Roles During Plant and Animal Colonization.Annual review of microbiology · 2024Review
- Deciphering the enigmatic PilY1 ofBiochemistry and biophysics reports · 2024Article
- A bacterial sense of touch: T4P retraction motor as a means of surface sensing byJournal of bacteriology · 2024Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
To initiate biofilm formation, it is critical for bacteria to sense a surface and respond precisely to activate downstream components of the biofilm program. Type 4 pili (T4P) and increasing levels of c-di-GMP have been shown to be important for surface sensing and biofilm formation, respectively; however, mechanisms important in modulating the levels of this dinucleotide molecule to define a precise output response are unknown. Here, using macroscopic bulk assays and single-cell tracking analyses of
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.