Evidence map›Paper›PMID 34168077›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Dual oxidase 1 promotes antiviral innate immunity.

Demba Sarr, Aaron D Gingerich, Nuha Milad Asthiwi, Faris Almutairi, Giuseppe A Sautto, Jeffrey Ecker, Tamás Nagy, Matthew B Kilgore, Joshua D Chandler, Ted M Ross and 2 more

Erratum issuedOpen access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 26 citations in OpenAlex.

  1. Review
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  4. Review
  5. DUOX2 regulates secreted factors in virus-infected respiratory epithelial cells that contribute to neutrophil attraction and activation.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2023
    Article
  6. Dual oxidase 1 is dispensable duringFrontiers in immunology · 2023
    Article
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  12. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Demba SarrDepartment of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA 30602.ORCID 0000-0002-8306-0433
Aaron D GingerichDepartment of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA 30602.
Nuha Milad AsthiwiDepartment of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA 30602.ORCID 0000-0001-5941-1806
Faris AlmutairiDepartment of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA 30602.
Giuseppe A SauttoCenter for Vaccines and Immunology, University of Georgia, Athens, GA 30602.ORCID 0000-0002-0273-2235
Jeffrey EckerCenter for Vaccines and Immunology, University of Georgia, Athens, GA 30602.
Tamás NagyDepartment of Pathology, College of Veterinary Medicine, University of Georgia, Athens, GA 30602.ORCID 0000-0003-3828-0485
Matthew B KilgoreDepartment of Pediatrics, Division of Pulmonary, Allergy and Immunology, Cystic Fibrosis, and Sleep Medicine, Emory University School of Medicine, Atlanta, GA 30322.
Joshua D ChandlerDepartment of Pediatrics, Division of Pulmonary, Allergy and Immunology, Cystic Fibrosis, and Sleep Medicine, Emory University School of Medicine, Atlanta, GA 30322.ORCID 0000-0003-3211-7935
Ted M RossDepartment of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA 30602.ORCID 0000-0003-1947-7469
Ralph A TrippDepartment of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA 30602.
Balázs RadaDepartment of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA 30602; radab@uga.edu.ORCID 0000-0002-9742-4955
University of Georgia · USEmory University · US

Funding

Neutrophil extracellular traps in cystic fibrosisR01HL136707 · NHLBI · UNIVERSITY OF GEORGIA · PI RADA, BALAZS · 2018 to 2021
$2.6M
Dual oxidase and lactoperoxidase in influenza infectionR01AI146857 · NIAID · UNIVERSITY OF GEORGIA · PI RADA, BALAZS, TRIPP, RALPH A · 2020 to 2024
$1.9M
The Role of Oxidative Epithelial Defenses in Influenza InfectionR21AI124189 · NIAID · UNIVERSITY OF GEORGIA · PI RADA, BALAZS, TRIPP, RALPH A · 2017 to 2018
$413k
NHLBI NIH HHS R01 HL136707NIAID NIH HHS R01 AI146857NIAID NIH HHS R21 AI124189
6 · The paper itself

Abstract

Dual oxidase 1 (DUOX1) is an NADPH oxidase that is highly expre-ssed in respiratory epithelial cells and produces H

Indexed as

Immunity, InnateAnimalsApoptosisBronchiCytokinesDisease Models, AnimalDual OxidasesEpithelial CellsHumansHydrogen PeroxideInfluenza, HumanLactoperoxidaseMiceNeuraminidaseOrthomyxoviridaeOrthomyxoviridae InfectionsCytokinesDual OxidasesHydrogen Peroxidehypothiocyanite ionLactoperoxidaseNA protein, influenza A virusNeuraminidaseRNA, ViralThiocyanatesViral ProteinsDual oxidase 1DUOX1hypothiocyaniteinfluenzalactoperoxidase

Identifiers

PMID34168077
PMCPMC8256044
OpenAlexW3176868492

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.