Evidence map›Paper›PMID 34168053›Full record

ArticleeNeuro

Sex and Pubertal Differences in the Maturational Trajectories of Sleep Spindles in the Transition from Childhood to Adolescence: A Population-Based Study.

Anna Ricci, Fan He, Susan L Calhoun, Jidong Fang, Alexandros N Vgontzas, Duanping Liao, Edward O Bixler, Magdy Younes, Julio Fernandez-Mendoza

Open access · goldAbstract read
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Sleep Across the Lifespan: A Neurobehavioral Perspective.Current sleep medicine reports · 2025
    Review
  8. Article
  9. Edward O. Bixler, PhD: from the Apollo project and chimpanzees to sleep epidemiology.Sleep advances : a journal of the Sleep Research Society · 2024
    Article
  10. Article
  11. Review
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Anna RicciSleep Research and Treatment Center, Department of Psychiatry and Behavioral Health, Penn State College of Medicine, Hershey, PA17033.
Fan HeDepartment of Public Health Sciences, Penn State College of Medicine, Hershey, PA17033.
Susan L CalhounSleep Research and Treatment Center, Department of Psychiatry and Behavioral Health, Penn State College of Medicine, Hershey, PA17033.
Jidong FangSleep Research and Treatment Center, Department of Psychiatry and Behavioral Health, Penn State College of Medicine, Hershey, PA17033.
Alexandros N VgontzasSleep Research and Treatment Center, Department of Psychiatry and Behavioral Health, Penn State College of Medicine, Hershey, PA17033.
Duanping LiaoDepartment of Public Health Sciences, Penn State College of Medicine, Hershey, PA17033.
Edward O BixlerSleep Research and Treatment Center, Department of Psychiatry and Behavioral Health, Penn State College of Medicine, Hershey, PA17033.
Magdy YounesSleep Disorders Centre, University of Manitoba, Winnipeg, ManitobaR3M 0A7, Canada.
Julio Fernandez-MendozaSleep Research and Treatment Center, Department of Psychiatry and Behavioral Health, Penn State College of Medicine, Hershey, PA17033 jfmendoza@psu.edu.
Pennsylvania State University · USUniversity of Manitoba · CA

Funding

Penn State Clinical and Translational Science InstituteUL1TR000127 · NCATS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI SINOWAY, LAWRENCE I · 2012 to 2015
$17.1M
The Penn State Child Sleep Cohort: Cardiometabolic and Neurocognitive Risk in Young AdulthoodR01HL136587 · NHLBI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI FERNANDEZ-MENDOZA, JULIO · 2018 to 2022
$3.7M
Sleep and cardio-metabolic risk factors: a prospective study of adolescentsR01HL097165 · NHLBI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI BIXLER, EDWARD O., LIAO, DUANPING · 2010 to 2013
$2.2M
PREVALENCE OF SLEEP DISORDERED BREATHING IN CHILDRENR01HL063772 · NHLBI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI BIXLER, EDWARD O. · 2001 to 2005
$1.3M
Sleep Cortical Dynamics and Neurobehavioral Risk in Children and Adolescents: A Longitudinal StudyR01MH118308 · NIMH · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI FERNANDEZ-MENDOZA, JULIO · 2019 to 2021
$1.2M
NCATS NIH HHS UL1 TR000127NHLBI NIH HHS R01 HL063772NHLBI NIH HHS R01 HL097165NHLBI NIH HHS R01 HL136587NIMH NIH HHS R01 MH118308
6 · The paper itself

Abstract

Sleep spindles, bursts of electroencephalogram (EEG) activity in the σ-frequency (11-16 Hz) range, may be biomarkers of cortical development. Studies capturing the transition to adolescence are needed to delineate age-related, sex-related, and pubertal-related changes in sleep spindles at the population-level. We analyzed the sleep EEG of 572 subjects 6-21 years (48% female) and 332 subjects 5-12 years (46% female) followed-up at 12-22 years. From 6 to 21 years, spindle density (

Indexed as

ElectroencephalographySleepAdolescentAdultChildFemaleHumansMaleNeurogenesisResearchSex Characteristicsadolescencebrain maturationchildhooddevelopmental biologypubertysleep spindles

Identifiers

PMID34168053
PMCPMC8281264
OpenAlexW3176168586

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.