ArticleThorax2022
Blood RNA sequencing shows overlapping gene expression across COPD phenotype domains.
Article in Thorax, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 15 citations in OpenAlex.
- Unfolding Immune Dysregulation in COPD: Identification of a Three-Gene Signature and Functional Validation ofInternational journal of molecular sciences · 2026Article
- Mechanisms and Risk Factors of Cognitive Impairment in COPD.CHEST pulmonary · 2026Article
- Molecular determinants of lung function decline: a multi-level analysis of gene expression.Respiratory research · 2025Article
- LaGrACE: estimating gene program dysregulation with latent regulatory network.Molecular systems biology · 2025Article
- LungGENIE: the lung gene-expression and network imputation engine.BMC genomics · 2025Article
- Protective factors against oxidative stress in COPD: focus on Nrf2-dependent antioxidant gene expression.Frontiers in medicine · 2025Review
- Development and validation of a mortality risk prediction model for chronic obstructive pulmonary disease: a cross-sectional study using probabilistic graphical modelling.EClinicalMedicine · 2024Article
- Multi-center Korean cohort study based on RNA-sequencing data targeting COPD patients.Scientific data · 2024Article
- Leveraging blood-based transcriptomics to detect acute cellular rejection in lung transplant.JHLT open · 2024Article
- Leveraging Omics to Predict Chronic Obstructive Pulmonary Disease Exacerbations: The "Immunome".American journal of respiratory and critical care medicine · 2023Article
- An interferon-inducible signature of airway disease from blood gene expression profiling.The European respiratory journal · 2022Article
- Development of a Blood-based Transcriptional Risk Score for Chronic Obstructive Pulmonary Disease.American journal of respiratory and critical care medicine · 2022Article
- Identifying miRNA-mRNA Networks Associated With COPD Phenotypes.Frontiers in genetics · 2021Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
rationaleCOPD can be assessed using multidimensional grading systems with components from three domains: pulmonary function tests, symptoms and systemic features. Clinically, measures may be used interchangeably, though it is not known if they share similar pathobiology.
objectiveTo use RNA sequencing (RNA-seq) to determine if there is an overlap in the underlying biological mechanisms and consequences driving different components of the multidimensional grading systems.
methodsWhole blood was collected for RNA-seq from current and former smokers in the Genetic Epidemiology of COPD study. We tested the overlap in gene expression and biological pathways associated with case-control status and quantitative COPD phenotypes within and between the three domains.
resultsIn 2647 subjects, there were 3030 genes differentially expressed in any of the three domains or case-control status. There were five genes that overlapped between the three domains and case-control status, including
conclusionsWe identified gene sets and pathways that overlap between 12 COPD-related phenotypes and case-control status. There were no pathways represented in the overlap between the three domains and case-control status, but we identified multiple genes that demonstrated a consistent pattern of expression across several of the phenotypes. Patterns of gene expression correlation were generally similar to the correlation of clinical phenotypes in the PFT and symptom domains but not the systemic features.
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