Trial reportAJNR. American journal of neuroradiology2021
Strength of Association between Infarct Volume and Clinical Outcome Depends on the Magnitude of Infarct Size: Results from the ESCAPE-NA1 Trial.
Trial report in AJNR. American journal of neuroradiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Guidelines for Neuroprognostication in Critically ill Adults with Acute Ischemic Stroke.Neurocritical care · 2026Guideline
- From therapeutic nihilism to armamentarium: A meta-analysis of randomized clinical trials assessing safety and efficacy of endovascular therapy for acute large ischemic strokes.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2026Pooled it
- Association of Minimal Clinically Important Difference With Infarct Volume in Clinical Poststroke Outcomes.Journal of the American Heart Association · 2025Trial
- Effect of IV Thrombolysis With Alteplase in Patients With Vessel Occlusion in the WAKE-UP Trial.Neurology · 2025Trial
- Unsuccessful Recanalization versus Medical Management of Patients with Large Ischemic Core : Analysis of the ANGEL-ASPECT Randomized Trial.Clinical neuroradiology · 2024Trial
- Functional Outcome Prediction in Acute Ischemic Stroke Using a Fused Imaging and Clinical Deep Learning Model.Stroke · 2023Trial
- Sex Differences in the Protective Effect of Brain Volume: Age Attenuates Protection in Women.Stroke (Hoboken, N.J.) · 2026Article
- Initial Experience With a Deep Learning Algorithm for Detecting Posterior Circulation Large Vessel Occlusion on Noncontrast Computed Tomography.Stroke (Hoboken, N.J.) · 2026Article
- Knockdown of endothelial Serpine1 improves stroke recovery by attenuating peri-infarct blood flow and blood-brain barrier disruption.Cell death & disease · 2026Article
- Efficacy and safety of minocycline on patients with acute anterior circulation ischaemic stroke undergoing mechanical thrombectomy (MIST-A): a multicentre, prospective, randomised, open-label, blinded-endpoint, phase 2 trial.The Lancet regional health. Western Pacific · 2026Article
- RNS60 RESCUE Trial in Acute Ischemic Stroke: Post Hoc Analysis in Participants Enrolled <12 Hours Since Last Known Well.Stroke (Hoboken, N.J.) · 2026Article
- Stroke Subtypes Drive Distinct Neurological, Cognitive, and Mortality Outcomes in UK Biobank Cohort.medRxiv : the preprint server for health sciences · 2026Article
- Brain age trajectories and cognition after stroke in two longitudinal cohorts.Brain communications · 2026Article
- Imaging research, diagnosis, and treatment advances of post-stroke cognitive impairment.Frontiers in neuroimaging · 2026Review
- Sex Differences in the Protective Effect of Brain Volume: Age Attenuates Protection in Females.medRxiv : the preprint server for health sciences · 2025Article
- The Diagnostic and Prognostic Value of Reticulated Platelets in Ischemic Stroke: Is Immature Platelet Fraction a New Biomarker?Medicina (Kaunas, Lithuania) · 2025Article
- Prevention of Metabolic Impairment by Dietary Nitrate in Overweight Male Mice Improves Stroke Outcome.Nutrients · 2025Article
- IFP35, a novel DAMP, aggravates neuroinflammation following acute ischemic stroke via TLR4/NF-κB/NLRP3 signaling.Journal of neuroinflammation · 2025Article
- Comparative Analysis of the ABC/2 Score and e-ASPECTS Software in the Determination of Acute Ischaemic Stroke Volume from Non-Contrast CT.Brain sciences · 2025Article
- Distance to thrombus, ischemic lesion volume and clinical outcome after thrombectomy for M1 middle cerebral artery occlusion.Wiener klinische Wochenschrift · 2025Article
Corrections and comments
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Authors and funding
20 authors.
Funding
Abstract
background and purposeInfarct volume is an important predictor of clinical outcome in acute stroke. We hypothesized that the association of infarct volume and clinical outcome changes with the magnitude of infarct size. MATERIALS AND
methodsData were derived from the Safety and Efficacy of Nerinetide in Subjects Undergoing Endovascular Thrombectomy for Stroke (ESCAPE-NA1) trial, in which patients with acute stroke with large-vessel occlusion were randomized to endovascular treatment plus either nerinetide or a placebo. Infarct volume was manually segmented on 24-hour noncontrast CT or DWI. The relationship between infarct volume and good outcome, defined as mRS 0-2 at 90 days, was plotted. Patients were categorized on the basis of visual grouping at the curve shoulders of the infarct volume/outcome plot. The relationship between infarct volume and adjusted probability of good outcome was fitted with linear or polynomial functions as appropriate in each group.
resultsWe included 1099 individuals in the study. Median infarct volume at 24 hours was 24.9 mL (interquartile range [IQR] = 6.6-92.2 mL). On the basis of the infarct volume/outcome plot, 4 infarct volume groups were defined (IQR = 0-15 mL, 15.1-70 mL, 70.1-200 mL, >200 mL). Proportions of good outcome in the 4 groups were 359/431 (83.3%), 219/337 (65.0%), 71/201 (35.3%), and 16/130 (12.3%), respectively. In small infarcts (IQR = 0-15 mL), no relationship with outcome was appreciated. In patients with intermediate infarct volume (IQR = 15-200 mL), there was progressive importance of volume as an outcome predictor. In infarcts of > 200 mL, outcomes were overall poor.
conclusionsThe relationship between infarct volume and clinical outcome varies nonlinearly with the magnitude of infarct size. Infarct volume was linearly associated with decreased chances of achieving good outcome in patients with moderate-to-large infarcts, but not in those with small infarcts. In very large infarcts, a near-deterministic association with poor outcome was seen.
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