Evidence map›Paper›PMID 34167660›Full record

ReviewProgress in brain research2021

From adults to pediatrics: A review noninvasive brain stimulation (NIBS) to facilitate recovery from brain injury.

Georgia H O'Leary, Dorothea D Jenkins, Patricia Coker-Bolt, Mark S George, Steve Kautz, Marom Bikson, Bernadette T Gillick, Bashar W Badran

Open access · greenAbstract readReview
In one paragraph

Review in Progress in brain research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
7.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Georgia H O'LearyDepartment of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, United States.
Dorothea D JenkinsDepartment of Pediatrics, Medical University of South Carolina, Charleston, SC, United States.
Patricia Coker-BoltDivision of Occupational Therapy, College of Health Professions, Medical University of South Carolina, Charleston, SC, United States.
Mark S GeorgeDepartment of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, United States; Ralph H. Johnson VA Medical Center, Charleston, SC, United States.
Steve KautzRalph H. Johnson VA Medical Center, Charleston, SC, United States; Department of Health Sciences and Research, Medical University of South Carolina, Charleston, SC, United States.
Marom BiksonDepartment of Biomedical Engineering, City College of New York, New York, NY, United States.
Bernadette T GillickDepartment of Rehabilitation Medicine, University of Minnesota, Minneapolis, MN, United States.
Bashar W BadranDepartment of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, United States. Electronic address: badran@musc.edu.
Medical University of South Carolina · USCity College of New York · USUniversity of Minnesota · US

Funding

Treating Depression and Enhancing Locomotor Recovery Post-strokeP20GM109040 · NIGMS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI KAUTZ, STEVEN A. · 2014 to 2024
$23.5M
Techniques DevelopmentP2CHD086844 · NICHD · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI THOMPSON, AIKO · 2015 to 2024
$12.7M
COCA: Project 4. Neurocircuit Strategy to Decrease Cocaine Cue ReactivityP50DA046373 · NIDA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI HANLON, COLLEEN A · 2019 to 2023
$9.9M
NICHD NIH HHS P2C HD086844NIDA NIH HHS P50 DA046373NIGMS NIH HHS P20 GM109040RRD VA IK6 RX003075
6 · The paper itself

Abstract

Stroke is a major problem worldwide that impacts over 100 million adults and children annually. Rehabilitation therapy is the current standard of care to restore functional impairments post-stroke, however its effects are limited and many patients suffer persisting functional impairments and life-long disability. Noninvasive Brain Stimulation (NIBS) has emerged as a potential rehabilitation treatment option in both adults and children with brain injury. In the last decade, Transcranial Magnetic Stimulation (TMS), Transcranial Direct Current Stimulation (tDCS) and Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) have been investigated to improve motor recovery in adults post-stroke. These promising adult findings using NIBS, however, have yet to be widely translated to the area of pediatrics. The limited studies exploring NIBS in children have demonstrated safety, feasibility, and utility of stimulation-augmented rehabilitation. This chapter will describe the mechanism of NIBS therapy (cortical excitability, neuroplasticity) that underlies its use in stroke and motor function and how TMS, tDCS, and taVNS are applied in adult stroke treatment paradigms. We will then discuss the current state of NIBS in early pediatric brain injury and will provide insight regarding practical considerations and future applications of NIBS in pediatrics to make this promising treatment option a viable therapy in children.

Indexed as

Brain InjuriesPediatricsTranscranial Direct Current StimulationAdultBrainChildHumansTranscranial Magnetic StimulationBrain injuryBrain stimulationCerebral palsyNIBSPediatricsStroketaVNStDCSTMStVNSVNS

Identifiers

PMID34167660
PMCPMC8855635
OpenAlexW3131793719

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.