SynthesisPsychological medicine2023
Longitudinal association between cardiovascular risk factors and depression in young people: a systematic review and meta-analysis of cohort studies.
Synthesis in Psychological medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 3 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- The relationship between cardiovascular health and common mental disorders among adults aged ≤ 50 years: a systematic review of observational studies.BMC psychiatry · 2026Pooled it
- Associations of cannabis use, tobacco use, and incident anxiety, mood, and psychotic disorders: a systematic review and meta-analysis.Psychological medicine · 2024Pooled it
- Identifying transdiagnostically relevant risk and protective factors for internalizing psychopathology: An umbrella review of longitudinal meta-analyses.Journal of psychiatric research · 2023Pooled it
- Social, psychological, and cultural dimensions of cardiovascular health among Hispanic/Latino adults: A narrative review of findings from the Hispanic Community Health Study/Study of Latinos.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2026Review
- Associations of sedentary behavior and weekday lifestyle with mental health among Chinese senior high school students.Frontiers in psychology · 2026Article
- Causal Relationships Between Major Depressive Disorder and Coronary Artery Disease Across Diverse Populations: A Bidirectional Mendelian Randomisation Study.Tropical medicine & international health : TM & IH · 2026Article
- Longitudinal Prediction of Adolescent Depression from Environmental and Polygenic Risk Scores.medRxiv : the preprint server for health sciences · 2025Article
- Identifying Cardiovascular Disease Risk Endotypes of Adolescent Major Depressive Disorder Using Exploratory Unsupervised Machine Learning.JAACAP open · 2025Article
- The Impact of Previously Diagnosed Depression on Early and One-Year Mortality in Patients with Acute Ischemic Stroke in Opole Province, Poland.Journal of clinical medicine · 2024Article
- Chronic stress in adulthood results in microvascular dysfunction and subsequent depressive-like behavior.Scientific reports · 2024Article
- Metabolic underpinnings of cancer-related fatigue.American journal of physiology. Endocrinology and metabolism · 2024Review
- Mediation of the Association Between Vascular Risk Factors and Depressive Symptoms by C-Reactive Protein.Biological psychiatry global open science · 2023Article
- Using Mendelian randomization analysis to determine the causal connection between unpleasant emotions and coronary atherosclerosis.Frontiers in cardiovascular medicine · 2023Article
- Frailty as an Independent Risk Factor for Depression in Patients With End-Stage Renal Disease: A Cross-Sectional Study.Frontiers in medicine · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundDepression is a common and serious mental illness that begins early in life. An association between cardiovascular disease (CVD) and subsequent depression is clear in adults. We examined associations between individual CVD risk factors and depression in young people.
methodsWe searched MEDLINE, EMBASE, and PsycINFO databases from inception to 1 January 2020. We extracted data from cohort studies assessing the longitudinal association between CVD risk factors [body mass index (BMI), smoking, systolic blood pressure (SBP), total cholesterol, high-density lipoprotein] and depression, measured using a validated tool in individuals with mean age of 24 years or younger. Random effect meta-analysis was used to combine effect estimates from individual studies, including odds ratio (OR) for depression and standardised mean difference for depressive symptoms.
resultsBased on meta-analysis of seven studies, comprising 15 753 participants, high BMI was associated with subsequent depression [pooled OR 1.61; 95% confidence interval (CI) 1.21-2.14;
conclusionsTargeting childhood/adolescent smoking and obesity may be important for the prevention of both CVD and depression across the lifespan. Further research on other CVD risk factors including blood pressure and cholesterol in young people is required.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.