Evidence map›Paper›PMID 34167552›Full record

ReviewCancer cell international2021

Chitosan nanoparticles as a promising tool in nanomedicine with particular emphasis on oncological treatment.

Javad Sharifi-Rad, Cristina Quispe, Monica Butnariu, Lia Sanda Rotariu, Oksana Sytar, Simona Sestito, Simona Rapposelli, Muhammad Akram, Mehwish Iqbal, Akash Krishna and 12 more

Open access · goldAbstract readReview
In one paragraph

Review in Cancer cell international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 103 papers.

0numbers the graph read from it
0cells of the map it votes in
103citing papers in PubMed
17.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

103 citing papers in PubMed, 273 citations in OpenAlex.

  1. Review
  2. Article
  3. Effects ofVeterinary and animal science · 2026
    Article
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  6. Article
  7. Article
  8. Bridging bioactive metabolites ofFrontiers in pharmacology · 2026
    Review
  9. Review
  10. Article
  11. Review
  12. Recent Developments in Nanoparticle-Hydrogel Hybrid Materials for Controlled Release.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  13. Review
  14. Article
  15. Review
  16. Review
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  19. Article
  20. Preparation ofInsects · 2024
    Article

43 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 13 institutions in 11 countries.

Javad Sharifi-RadPhytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. javad.sharifirad@gmail.com.ORCID http://orcid.org/0000-0002-7301-8151
Cristina QuispeFacultad de Ciencias de La Salud, Universidad Arturo Prat, Avda. Arturo Prat 2120, 1110939, Iquique, Chile.
Monica ButnariuBanat's University of Agricultural Sciences and Veterinary Medicine "King Michael I of Romania" From Timisoara, Calea Aradului 119, 300645, Timis, Romania. monicabutnariu@yahoo.com.
Lia Sanda RotariuBanat's University of Agricultural Sciences and Veterinary Medicine "King Michael I of Romania" From Timisoara, Calea Aradului 119, 300645, Timis, Romania.
Oksana SytarDepartment of Plant Biology Department, Institute of Biology, Taras Shevchenko National University of Kyiv, Kyiv, 01033, Ukraine.
Simona SestitoDepartment of Plant Physiology, Slovak University of Agriculture, Nitra, 94976, Slovak Republic.
Simona RapposelliDepartment of Plant Physiology, Slovak University of Agriculture, Nitra, 94976, Slovak Republic.
Muhammad AkramDepartment of Eastern Medicine and Surgery, Directorate of Medical Sciences, GC University Faisalabad, Faisalabad, Pakistan.
Mehwish IqbalInstitute of Health Management, Dow University of Health Sciences, Karachi, Pakistan.
Akash KrishnaDepartment of Chemistry, Manipal Institute of Technology, Manipal Academy of Higher Education, Manipal, 576104, India.
Nanjangud Venkatesh Anil KumarDepartment of Chemistry, Manipal Institute of Technology, Manipal Academy of Higher Education, Manipal, 576104, India.
Susana S BragaLAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193, Aveiro, Portugal.
Susana M CardosoLAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193, Aveiro, Portugal.
Karolina JafernikDepartment of Pharmaceutical Botany, Medical College, Jagiellonian University, Medyczna 9, 30-688, Kraków, Poland.
Halina EkiertDepartment of Pharmaceutical Botany, Medical College, Jagiellonian University, Medyczna 9, 30-688, Kraków, Poland.
Natália Cruz-MartinsFaculty of Medicine, University of Porto, Porto, Portugal. ncmartins@med.up.pt.
Agnieszka SzopaDepartment of Pharmaceutical Botany, Medical College, Jagiellonian University, Medyczna 9, 30-688, Kraków, Poland. a.szopa@uj.edu.pl.
Marcelo VillagranBiomedical Science Research Laboratory and Scientific-Technological Center for the Sustainable Development of the Coastline, Universidad Catolica de La Santisima Concepcion, Concepcion, Chile.
Lorena MardonesBiomedical Science Research Laboratory and Scientific-Technological Center for the Sustainable Development of the Coastline, Universidad Catolica de La Santisima Concepcion, Concepcion, Chile.
Miquel MartorellDepartment of Nutrition and Dietetics, Faculty of Pharmacy, and Centre for Healthy Living, University of Concepción, 4070386, Concepción, Chile.
Anca Oana DoceaDepartment of Toxicology, University of Medicine and Pharmacy of Craiova, 200349, Craiova, Romania.
Daniela CalinaDepartment of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, 200349, Craiova, Romania. calinadaniela@gmail.com.
Jagiellonian University · PLManipal Academy of Higher Education · INRede de Química e Tecnologia · PTUniversidad Católica de la Santísima Concepción · CLUniversity of Medicine and Pharmacy of Craiova · ROUniversity of Pisa · ITUnivesity of Life Science "King Mihai I" from Timisoara · ROArturo Prat University · CLDow University of Health Sciences · PKTaras Shevchenko National University of Kyiv · UAUniversidad del Azuay · ECUniversidade do Porto · PTUniversity of Concepción · CL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The study describes the current state of knowledge on nanotechnology and its utilization in medicine. The focus in this manuscript was on the properties, usage safety, and potentially valuable applications of chitosan-based nanomaterials. Chitosan nanoparticles have high importance in nanomedicine, biomedical engineering, discovery and development of new drugs. The manuscript reviewed the new studies regarding the use of chitosan-based nanoparticles for creating new release systems with improved bioavailability, increased specificity and sensitivity, and reduced pharmacological toxicity of drugs. Nowadays, effective cancer treatment is a global problem, and recent advances in nanomedicine are of great importance. Special attention was put on the application of chitosan nanoparticles in developing new system for anticancer drug delivery. Pre-clinical and clinical studies support the use of chitosan-based nanoparticles in nanomedicine. This manuscript overviews the last progresses regarding the utilization, stability, and bioavailability of drug nanoencapsulation with chitosan and their safety.

Indexed as

CancerChitosanNanomedicineNanoparticlesTargeted therapy

Identifiers

PMID34167552
PMCPMC8223345
OpenAlexW3173169652

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.