Evidence map›Paper›PMID 34167531›Full record

Observational studyBMC surgery2021

Bariatric surgery for non-alcoholic fatty liver disease in individuals with obesity (Base-NAFLD): protocol of a prospective multicenter observational follow-up study.

Luyang Wei, Mengyi Li, Na Zeng, Yang Liu, Rixing Bai, Nengwei Zhang, Jinghai Song, Pin Zhang, Qiyuan Yao, Zhenghan Yang and 4 more

Registry-linked trialOpen access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMC surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04366999 (Effectiveness of Bariatric Surgery for Nonalcoholic Fatty Liver Diseases/Nonalcoholic Steatohepatitis With Fibrosis), which is not on this map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04366999 recruitingnot on this map

Effectiveness of Bariatric Surgery for Nonalcoholic Fatty Liver Diseases/Nonalcoholic Steatohepatitis With Fibrosis : A Prospective, Multicentric Cohort Study

TypeobservationalSponsorBeijing Friendship HospitalRan2020 to 2026Enrolled320ConditionsBariatric Surgery Candidate, NAFLD, NASH With FibrosisArmsSG, RYGB, OAGB
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Understanding the Burden of Nonalcoholic Fatty Liver Disease: Time for Action.Diabetes spectrum : a publication of the American Diabetes Association · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 1 country.

Luyang Wei *Department of General Surgery, Beijing Friendship Hospital, Capital Medical University and National Clinical Research Center for Digestive Diseases, No. 95 Yong-an Road, Xi-Cheng, Beijing, 100050, China.
Mengyi Li *Department of General Surgery, Beijing Friendship Hospital, Capital Medical University and National Clinical Research Center for Digestive Diseases, No. 95 Yong-an Road, Xi-Cheng, Beijing, 100050, China.
Na Zeng *National Clinical Research Center for Digestive Diseases, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, China.
Yang LiuDepartment of General Surgery, Beijing Friendship Hospital, Capital Medical University and National Clinical Research Center for Digestive Diseases, No. 95 Yong-an Road, Xi-Cheng, Beijing, 100050, China.
Rixing BaiDepartment of General Surgery, Tiantan Hospital, Capital Medical University, No. 119, South West Ring Road, Fengtai, Beijing, 100070, China.
Nengwei ZhangDepartment of General Surgery, Beijing Shijitan Hospital, Capital Medical University/Peking University, Ninth Clinical Medical College, Tieyilu 10, Yangfangdian, Haidian, Beijing, 100038, China.
Jinghai SongDepartment of General Surgery, Beijing Hospital, National Center of Gerontology, No. 1 Dahua Road, Dong Dan, Dong-Cheng, Beijing, 100730, China.
Pin ZhangDepartment of Bariatric and Metabolic Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, No.600 Yishan Road, Shanghai, 200233, China.
Qiyuan YaoCenter for Obesity and Metabolic Surgery, Huashan Hospital, Fudan University, No. 12 Middle Wulumuqi Road, Shanghai, 200040, China.
Zhenghan YangDepartment of Radiology, Beijing Friendship Hospital, Capital Medical University, No.95 Yong-an Road, Xi-Cheng, Beijing, 100050, China.
Xinyan ZhaoLiver Research Cennter, Beijing Friendship Hospital, Capital Medical University, No.95 Yong-an Road, Xi-Cheng, Beijing, 100050, China.
Yun ZhangDepartment of Biobank, Beijing Friendship Hospital, Capital Medical University, No.95 Yong-an Road, Xi-Cheng, Beijing, 100050, China.
Peng ZhangDepartment of General Surgery, Beijing Friendship Hospital, Capital Medical University and National Clinical Research Center for Digestive Diseases, No. 95 Yong-an Road, Xi-Cheng, Beijing, 100050, China. zhangpg@yahoo.com.
Zhongtao ZhangDepartment of General Surgery, Beijing Friendship Hospital, Capital Medical University and National Clinical Research Center for Digestive Diseases, No. 95 Yong-an Road, Xi-Cheng, Beijing, 100050, China. zhangzht@ccmu.edu.cn.
Capital Medical University · CNBeijing Friendship Hospital · CNNational Clinical Research Center for Digestive Diseases · CNBeijing Hospital · CNBeijing Tian Tan Hospital · CNFudan University · CNShanghai Jiao Tong University · CN

Funding

Capital's Funds for Health Improvement and Research Grant No. 2020-1-2021
6 · The paper itself

Abstract

backgroundBariatric surgery may be indicated in patients with nonalcoholic fatty liver disease (NAFLD) to achieve and maintain the degree of weight loss required to ensure therapeutic effects. However, bariatric surgery is still underrecognized in the treatment of NAFLD, including its inflammatory subtype, nonalcoholic steatohepatitis (NASH). Moreover, there is a lack of follow-up outcome data on different types of bariatric surgery in patients with NAFLD. This study aims to adequately assess the effect of bariatric surgery on NAFLD remission in obese patients.

methodsThis prospective multicentre observational follow-up study will include 142 obese patients with NAFLD scheduled to undergo one of the following surgical procedures: sleeve gastrostomy, Roux-en-Y gastric bypass, and one anastomosis gastric bypass. The primary outcome is the complete remission rate of NAFLD one year postoperatively, which is defined by liver fat fraction < 5% on magnetic resonance imaging; the secondary outcomes includes (i) changes in NASH and liver fibrosis biopsy findings, (ii) changes in body weight and abdominal adipose weight, (iii) resolution of obesity-related comorbidities, and (iv) incidence of adverse events. A long-term follow-up related to this study will also be conducted. DISCUSSION: This study will provide a necessary and preliminary foundation for the early identification and targeted treatment of patients with NAFLD who can be referred for bariatric surgery, as indicated for management of obesity and metabolic disease.

trial registrationClinicaltrials.gov: NCT04366999. Registered 21 April 2020. ( https://clinicaltrials.gov/ct2/show/NCT04366999 ).

Indexed as

Bariatric SurgeryGastric BypassNon-alcoholic Fatty Liver DiseaseObesity, MorbidFollow-Up StudiesHumansMulticenter Studies as TopicObesityObservational Studies as TopicProspective StudiesTreatment OutcomeBariatric surgeryMetabolic associated fatty liver diseaseNon-alcoholic fatty liver diseaseOne anastomosis gastric bypassRoux-en-Y gastric bypassSleeve gastrostomy

Identifiers

PMID34167531
PMCPMC8223375
OpenAlexW3175446821

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.