ArticleAnalytical chemistry2021
Single-Entity Electrochemistry for Digital Biosensing at Ultralow Concentrations.
Article in Analytical chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 24 citations in OpenAlex.
- Beyond ensemble averages: single-entity approaches for complex systems.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2026Review
- Unblocking a Path for Single Entity Electrochemistry in Digital Sensing.ACS electrochemistry · 2025Article
- Direct Single-Impact Electrochemistry Using Silver Nanoparticles as a "Digital" Readout for Biosensing Applications.ACS sensors · 2025Review
- Resistive Pulse Sensing of Pre-Nucleation Activities during Single-Entity Lysozyme Crystallization on Single Nanopipettes.Sensors and actuators reports · 2025Article
- Superior Single-Entity Electrochemistry Performance of Capping Agent-Free Gold Nanoparticles Compared to Citrate-Capped Gold Nanoparticles.Nanomaterials (Basel, Switzerland) · 2024Article
- Recent Developments in Single-Entity Electrochemistry.Analytical chemistry · 2024Review
- Metabolic and Oxidative Stress Effects on the Spectroelectrochemical Behavior of SingleChemical & biomedical imaging · 2023Article
- Utilizing the Oxygen Reduction Reaction in Particle Impact Electrochemistry: A Step toward Mediator-Free Digital Electrochemical Sensors.ACS omega · 2023Article
- Precise Electrochemical Sizing of Individual Electro-Inactive Particles.Journal of visualized experiments : JoVE · 2023Article
- Quantifying PON1 on HDL with nanoparticle-gated electrokinetic membrane sensor for accurate cardiovascular risk assessment.Nature communications · 2023Article
- Ring Ultramicroelectrodes for Current-Blockade Particle-Impact Electrochemistry.Analytical chemistry · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Quantifying ultralow analyte concentrations is a continuing challenge in the analytical sciences in general and in electrochemistry in particular. Typical hurdles for affinity sensors at low concentrations include achieving sufficiently efficient mass transport of the analyte, dealing with slow reaction kinetics, and detecting a small transducer signal against a background signal that itself fluctuates slowly in time. Recent decades have seen the advent of methods capable of detecting single analytes ranging from the nanoscale to individual molecules, representing the ultimate mass sensitivity to these analytes. However, single-entity detection does not automatically translate into a superior concentration sensitivity. This is largely because electrochemical transducers capable of such detection are themselves miniaturized, exacerbating mass transport and binding kinetic limitations. In this Perspective, we discuss how these challenges can be tackled through so-called digital sensing: large arrays of separately addressable single-entity detectors that provide real-time information on individual binding events. We discuss the advantages of this approach and the barriers to its implementation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.