Evidence map›Paper›PMID 34166717›Full record

ArticleRadiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology2021

Commissioning and clinical implementation of an Autoencoder based Classification-Regression model for VMAT patient-specific QA in a multi-institution scenario.

Ruijie Yang, Xueying Yang, Le Wang, Dingjie Li, Yuexin Guo, Ying Li, Yumin Guan, Xiangyang Wu, Shouping Xu, Shuming Zhang and 3 more

Erratum issuedAbstract readMulticenter Study
In one paragraph

Article in Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Ruijie YangDepartment of Radiation Oncology, Peking University Third Hospital, Beijing, China.
Xueying YangSchool of Physics, Beihang University, Beijing, China.
Le WangBrainnetome Center & National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, China; School of Artificial Intelligence, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Beijing, China.
Dingjie LiDepartment of Radiation Therapy, Henan Cancer Hospital, Zhengzhou, China.
Yuexin GuoDepartment of Radiation Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Ying LiDepartment of Oncology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Yumin GuanDepartment of Radiation Therapy, Yantai Yuhuangding Hospital, Yantai, China.
Xiangyang WuDepartment of Radiotherapy, Shanxi Provincial Cancer Hospital, Xi'an, China.
Shouping XuDepartment of Radiation Oncology, General Hospital of People's Liberation Army, Beijing, China.
Shuming ZhangDepartment of Radiation Oncology, Peking University Third Hospital, Beijing, China; Department of Ultrasound, Beijing Hospital, Beijing, China.
Maria F ChanMedical Physics Department, Memorial Sloan Kettering Cancer Center, New York, NY, United States.
Lisheng GengSchool of Physics, Beihang University, Beijing, China; Beijing Advanced Innovation Center for Big Data-Based Precision Medicine, School of Medicine and Engineering, Beihang University, Beijing, China. Electronic address: lisheng.geng@buaa.edu.cn.
Jing SuiSchool of Artificial Intelligence, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Beijing, China; State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China.. Electronic address: jsui@bnu.edu.cn.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

background and purposeTo commission and implement an Autoencoder based Classification-Regression (ACLR) model for VMAT patient-specific quality assurance (PSQA) in a multi-institution scenario. MATERIALS AND

methods1835 VMAT plans from seven institutions were collected for the ACLR model commissioning and multi-institutional validation. We established three scenarios to validate the gamma passing rates (GPRs) prediction and classification accuracy with the ACLR model for different delivery equipment, QA devices, and treatment planning systems (TPS). The prediction performance of the ACLR model was evaluated using mean absolute error (MAE) and root mean square error (RMSE). The classification performance was evaluated using sensitivity and specificity. An independent end-to-end test (E2E) and routine QA of the ACLR model were performed to validate the clinical use of the model.

resultsFor multi-institution validations, the MAEs were 1.30-2.80% and 2.42-4.60% at 3%/3 mm and 3%/2 mm, respectively, and RMSEs were 1.55-2.98% and 2.83-4.95% at 3%/3 mm and 3%/2 mm, respectively, with different delivery equipment, QA devices, and TPS, while the sensitivity was 90% and specificity was 70.1% at 3%/2 mm. For the E2E, the deviations between the predicted and measured results were within 3%, and the model passed the consistency check for clinical implementation. The predicted results of the model were the same in daily QA, while the deviations between the repeated monthly measured GPRs were all within 2%.

conclusionsThe performance of the ACLR model in multi-institution scenarios was validated on a large scale. Routine QA of the ACLR model was established and the model could be used for VMAT PSQA clinically.

Indexed as

Radiotherapy, Intensity-ModulatedGamma RaysHumansQuality Assurance, Health CareRadiometryRadiotherapy DosageRadiotherapy Planning, Computer-AssistedSensitivity and SpecificityClinical implementationCommissioningMachine learningMulti-institution validationVMAT patient-specific QA

Identifiers

PMID34166717
PMCPMC9388201

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.