ArticleMolecular cell2021
Gating movements and ion permeation in HCN4 pacemaker channels.
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Article in Molecular cell, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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57citing papers in PubMed
5.2field-weighted citation impact, top 3% of its field
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Who cites it
57 citing papers in PubMed, 91 citations in OpenAlex.
- Sequential membrane remodeling by cholesterol distinctly modulates HCN channels in naïve and neuropathic DRG neurons.The Journal of general physiology · 2026Article
- Structure mirroring function: What's the 'matter' with the funny current?The Journal of physiology · 2026Review
- The proximal N-terminus of IRAG is required for potentiation of HCN4 channels.bioRxiv : the preprint server for biology · 2026Article
- Selectivity Filter Dynamics Define Ion Conductance and Selectivity Differences in CNG and HCN Channels.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Structural determinants of voltage sensitivity in hyperpolarization-activated ion channels and their persistence in the evolutionary scale.Pflugers Archiv : European journal of physiology · 2026Article
- AMPK-mediated HCN4 channel phosphorylation contributes to age-related intrinsic bradycardia.The Journal of general physiology · 2026Article
- An inter-subunit path is required for entropically-driven and negatively cooperative binding of cyclic nucleotides in the HCN2 channel.Communications biology · 2026Article
- Proton-selective conductance and gating of the lysosomal cation channel TMEM175.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- A rare HCN4 variant combined with sick sinus syndrome, left ventricular noncompaction, and complex congenital heart disease.Channels (Austin, Tex.) · 2025Article
- Extracellular activation of HCN4 by a subtype-specific nanobody.Nature communications · 2025Article
- Amelioration of Chemotherapy Induced Neuropathic Pain using Novel Nicotinic Acid Derivatives with possible HCN channel binding ability.Molecular neurobiology · 2025Article
- Modular architecture of KEMBO reports · 2025Review
- Pore-Opening and Ion-Conduction Mechanism in Channelrhodopsins C1C2, ChR2, and iChloC by Computational Electrophysiology and Constant-pH Simulations.Journal of chemical information and modeling · 2025Article
- HCN4 channels sense temperature and determine heart rate responses to heat.Nature communications · 2025Article
- Cryo-EM structures of Arabidopsis CNGC1 and CNGC5 reveal molecular mechanisms underlying gating and calcium selectivity.Nature plants · 2025Article
- GORK KNature communications · 2025Article
- Subunit-specific conductance of single homomeric and heteromeric HCN pacemaker channels at femtosiemens resolution.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Voltage sensors.Molecular pharmacology · 2025Review
- A propofol binding site in the voltage sensor domain mediates inhibition of HCN1 channel activity.Science advances · 2025Article
- Membrane lipid nanodomains modulate HCN pacemaker channels in nociceptor DRG neurons.Nature communications · 2024Article
Corrections and comments
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Authors and funding
22 authors at 5 institutions in 4 countries.
Andrea SaponaroDepartment of Biosciences, University of Milan, Milan, Italy.
Daniel BauerDepartment of Biology, TU-Darmstadt, Darmstadt, Germany.
M Hunter GieseDepartment of Physiology and Cellular Biophysics, Columbia University, New York, NY, USA.
Paolo SwuecDepartment of Biosciences, University of Milan, Milan, Italy; Pediatric Research Center "Romeo ed Enrica Invernizzi," University of Milan, Milan, Italy.
Alessandro PorroDepartment of Biosciences, University of Milan, Milan, Italy.
Federica GasparriDepartment of Biosciences, University of Milan, Milan, Italy.
Atiyeh Sadat SharifzadehDepartment of Biosciences, University of Milan, Milan, Italy.
Antonio Chaves-SanjuanDepartment of Biosciences, University of Milan, Milan, Italy; Pediatric Research Center "Romeo ed Enrica Invernizzi," University of Milan, Milan, Italy.
Laura AlberioDepartment of Biosciences, University of Milan, Milan, Italy; Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK.
Giacomo ParisiCenter for Life Nano Science, Istituto Italiano di Tecnologia, Rome, Italy.
Gabriele CeruttiDepartment of Biochemical Sciences, Sapienza University of Rome, Rome, Italy.
Oliver B ClarkeDepartment of Physiology and Cellular Biophysics, Columbia University, New York, NY, USA; Department of Anesthesiology, Columbia University, New York, NY, USA.
Kay HamacherDepartment of Biology, TU-Darmstadt, Darmstadt, Germany.
Henry M ColecraftDepartment of Physiology and Cellular Biophysics, Columbia University, New York, NY, USA.
Filippo ManciaDepartment of Physiology and Cellular Biophysics, Columbia University, New York, NY, USA.
Wayne A HendricksonDepartment of Physiology and Cellular Biophysics, Columbia University, New York, NY, USA; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA.
Steven A SiegelbaumDepartment of Neuroscience, Zuckerman Institute, Columbia University, New York, NY, USA.
Dario DiFrancescoDepartment of Biosciences, University of Milan, Milan, Italy; Institute of Biophysics-Milano, Consiglio Nazionale delle Ricerche, Rome, Italy.
Martino BolognesiDepartment of Biosciences, University of Milan, Milan, Italy; Pediatric Research Center "Romeo ed Enrica Invernizzi," University of Milan, Milan, Italy.
Gerhard ThielDepartment of Biology, TU-Darmstadt, Darmstadt, Germany.
Bina SantoroDepartment of Neuroscience, Zuckerman Institute, Columbia University, New York, NY, USA. Electronic address: bs73@columbia.edu.
Anna MoroniDepartment of Biosciences, University of Milan, Milan, Italy; Institute of Biophysics-Milano, Consiglio Nazionale delle Ricerche, Rome, Italy. Electronic address: anna.moroni@unimi.it.
University of Milan · ITColumbia University · USTechnical University of Darmstadt · DEItalian Institute of Technology · ITSapienza University of Rome · IT
Funding
TRD #3: An automated and streamlined pipeline for in-situ molecular microscopyP41GM103310 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI DE MARCO, ALEX, KIEFT, JEFFREY S · 2012 to 2021
$14.7MTraining (303-338)P41GM116799 · NIGMS · NEW YORK STRUCTURAL BIOLOGY CENTER · PI HENDRICKSON, WAYNE A. · 2016 to 2020
$7.1MProposal for an Administrative Supplement for Equipment Purchases for NIGMS Awardees NOT-GM-18-022R01GM107462 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI HENDRICKSON, WAYNE A. · 2014 to 2021
$3.6MStructural Studies of HCN Channels in Health and DiseaseR01NS109366 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI HENDRICKSON, WAYNE A., SIEGELBAUM, STEVEN A · 2019 to 2023
$2.1MANOMALOUS-SCATTERING STUDIES OF MACROMOLECULAR STRUCTURER37GM034102 · NIGMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI HENDRICKSON, WAYNE A. · 1994 to 2003
$1.4MAcquisition of Detector for JEOL 3200 FSC Electron MicroscopeS10OD019994 · OD · NEW YORK STRUCTURAL BIOLOGY CENTER · PI CARRAGHER, BRIDGET OLIVIA · 2015 to 2015
$600kNIGMS NIH HHS P41 GM103310NIGMS NIH HHS P41 GM116799NIGMS NIH HHS R01 GM107462NIGMS NIH HHS R37 GM034102NIH HHS S10 OD019994NINDS NIH HHS R01 NS109366
Abstract
The HCN1-4 channel family is responsible for the hyperpolarization-activated cation current I
Indexed as
Cell LineCell Membrane PermeabilityCryoelectron MicroscopyCyclic AMPHEK293 CellsHumansHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsIon Channel GatingIonsMuscle ProteinsPotassium ChannelsCyclic AMPHCN4 protein, humanHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsIonsMuscle ProteinsPotassium ChannelscAMPcryo-EMgatingHCN4metal ionmolecular dynamicspacemakerpermeationporeselectivity
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.