Evidence map›Paper›PMID 34166605›Full record

ArticleCurrent biology : CB2021

Capicua is a fast-acting transcriptional brake.

Aleena L Patel, Lili Zhang, Shannon E Keenan, Christine A Rushlow, Cécile Fradin, Stanislav Y Shvartsman

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current biology : CB, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Review
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  4. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Aleena L PatelDepartment of Chemical and Biological Engineering, Princeton University, Princeton, NJ 08540, USA; Department of Molecular Biology, Princeton University, Princeton, NJ 08540, USA; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08540, USA.
Lili ZhangDepartment of Physics and Astronomy, McMaster University, Hamilton, ON L8S 4K1, Canada.
Shannon E KeenanDepartment of Chemical and Biological Engineering, Princeton University, Princeton, NJ 08540, USA; Department of Molecular Biology, Princeton University, Princeton, NJ 08540, USA; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08540, USA.
Christine A RushlowDepartment of Biology, New York University, New York, NY 10003, USA.
Cécile FradinDepartment of Physics and Astronomy, McMaster University, Hamilton, ON L8S 4K1, Canada; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 4K1, Canada. Electronic address: fradin@physics.mcmaster.ca.
Stanislav Y ShvartsmanDepartment of Molecular Biology, Princeton University, Princeton, NJ 08540, USA; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08540, USA; Center for Computational Biology, Flatiron Institute, New York, NY 10010, USA. Electronic address: stas@princeton.edu.

Funding

Regulation of zygotic genome activation by ZeldaR01GM063024 · NIGMS · NEW YORK UNIVERSITY · PI RUSHLOW, CHRISTINE A · 2002 to 2020
$5.2M
Systems biology of MAPK signaling in early drosophila embryoR01GM086537 · NIGMS · PRINCETON UNIVERSITY · PI BURDINE, REBECCA D., GOLDSMITH, ELIZABETH J. · 2011 to 2018
$3.1M
Harnessing optogenetics to diagnose and therapeutically rewire cancer cell signalingDP2EB024247 · NIBIB · PRINCETON UNIVERSITY · PI TOETTCHER, JARED E · 2016 to 2016
$2.4M
Mechanisms of signal integration in developmental control of organ size and tissue patterningR01HD085870 · NICHD · UNIVERSITY OF MASSACHUSETTS BOSTON · PI VERAKSA, ALEXEY · 2016 to 2020
$1.6M
Optogenetic control of spatio-temporal patterning in early embryogenesisF32GM119297 · NIGMS · PRINCETON UNIVERSITY · PI JOHNSON, HEATH E · 2016 to 2018
$173k
NIBIB NIH HHS DP2 EB024247NICHD NIH HHS R01 HD085870NIGMS NIH HHS F32 GM119297NIGMS NIH HHS R01 GM063024NIGMS NIH HHS R01 GM086537
6 · The paper itself

Abstract

Even though transcriptional repressors are studied with ever-increasing molecular resolution, the temporal aspects of gene repression remain poorly understood. Here, we address the dynamics of transcriptional repression by Capicua (Cic), which is essential for normal development and is commonly mutated in human cancers and neurodegenerative diseases.

Indexed as

Drosophila ProteinsHMGB ProteinsRepressor ProteinsAnimalsDrosophilaGene Expression Regulation, DevelopmentalHumanscic protein, DrosophilaCIC protein, humanDrosophila ProteinsHMGB ProteinsRepressor ProteinsburstingCapicuaDrosophilaERK signalingphotoswitchable MEKrepressortranscription

Identifiers

PMID34166605
PMCPMC8612007

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.