ArticleNeuron2021
A human colliculus-pulvinar-amygdala pathway encodes negative emotion.
Article in Neuron, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.
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Who cites it
43 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Neural activities during the Processing of unattended and unseen emotional faces: a voxel-wise Meta-analysis.Brain imaging and behavior · 2022Pooled it
- Distinct Representations of Irrelevant Emotional Information in the Visual Network Are Associated With Psychopathology in Youth.Biological psychiatry global open science · 2026Article
- An auditory "low road" for threat processing in humans sensitive to fast temporal cues.iScience · 2026Article
- Weakening of Subcortical and Strengthening of Cortical Visual Pathways Across Early Adolescence.Human brain mapping · 2026Article
- Seeing Through Feeling: Dynamic Interplay Between Emotion and Visual Perception.Brain sciences · 2026Review
- A conserved pulvinar projection to the amygdala revealed in macaque monkeys (Macaca mulatta).Brain structure & function · 2026Article
- Multimodal EEG-MRI Neuroimaging in Schizophrenia-A Systematic and Mechanistic Review.Journal of clinical medicine · 2026Review
- Massage Regulates Brain Plasticity in Chronic Sciatic Nerve Compression Injury Rats: A Study Based on Resting-State Functional Magnetic Resonance Imaging.Brain and behavior · 2026Article
- A Direct Auditory Subcortical Route to the Amygdala Associated with Fear in Humans.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Precision Imaging for Intraindividual Investigation of the Reward Response.Human brain mapping · 2026Article
- Human superior colliculus pathways represent the form and motion of looming objects.Cell reports · 2026Article
- A predictive processing framework for body-oriented trauma intervention: a hypothesis illustrated by Body Connect Therapy.Frontiers in psychology · 2026Article
- In vivo parcellation of the human superior colliculus from brain-wide probabilistic connectivity.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Subcortical modulation of the salience network during negative emotional processing in mood and anxiety disorders.Molecular psychiatry · 2025Article
- Spatiotemporal dynamics of amygdala during implicit and explicit facial emotional recognition in major depressive disorder: An MEG study.Psychological medicine · 2025Article
- Article
- Neural Representation of Associative Threat Learning in Pulvinar Divisions, Lateral Geniculate Nucleus, and Mediodorsal Thalamus in Humans.bioRxiv : the preprint server for biology · 2025Article
- Alterations of brain white matter network topological properties in overt hypothyroidism.Endocrine connections · 2025Article
- A distributed subcortical circuit linked to instrumental information-seeking about threat.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Neck and mind: exploring emotion processing in cervical dystonia.Frontiers in neuroscience · 2025Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Animals must rapidly respond to threats to survive. In rodents, threat-related signals are processed through a subcortical pathway from the superior colliculus to the amygdala, a putative "low road" to affective behavior. This pathway has not been well characterized in humans. We developed a novel pathway identification framework that uses pattern recognition to identify connected neural populations and optimize measurement of inter-region connectivity. We first verified that the model identifies known thalamocortical pathways with high sensitivity and specificity in 7 T (n = 56) and 3 T (n = 48) fMRI experiments. Then we identified a human functional superior colliculus-pulvinar-amygdala pathway. Activity in this pathway encodes the intensity of normative emotional responses to negative images and sounds but not pleasant images or painful stimuli. These results provide a functional description of a human "low road" pathway selective for negative exteroceptive events and demonstrate a promising method for characterizing human functional brain pathways.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.