Evidence map›Paper›PMID 34166585›Full record

ArticleAnnals of clinical and translational neurology2021

Sarcoidosis and neuromyelitis optica in a patient with optic neuritis - a case report.

Michael A Foster, Sara Collorone, Jacqueline Palace, James Acheson, Ahmed T Toosy

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of clinical and translational neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 91% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Trident Sign in Neuromyelitis Optica Spectrum Disorder.Annals of Indian Academy of Neurology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Michael A FosterDepartment of Neuroinflammation, UCL Queen Square Institute of Neurology, London, UK.ORCID 0000-0001-7201-7475
Sara ColloroneDepartment of Neuroinflammation, UCL Queen Square Institute of Neurology, London, UK.ORCID 0000-0003-1506-8983
Jacqueline PalaceNuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford, UK.
James AchesonStrabismus and Neuro-Ophthalmology Service, Moorfields Eye Hospital NHS Foundation Trust, London, UK.
Ahmed T ToosyDepartment of Neuroinflammation, UCL Queen Square Institute of Neurology, London, UK.ORCID 0000-0002-4441-3750
National Hospital for Neurology and Neurosurgery · GBJohn Radcliffe Hospital · GBMoorfields Eye Hospital NHS Foundation Trust · GB

Funding

Medical Research Council MR/S026088/1MRC MR/S026088/1NIMHD NIH HHS L60 MD001003
6 · The paper itself

Abstract

We present a case of atypical recurrent optic neuritis. A man in his 50s presented with right optic neuritis and profound visual loss, associated with elevated inflammatory markers. Lymph-node biopsy was consistent with sarcoidosis. Aquaporin-4 antibodies were also present. Three months following corticosteroid treatment, his right optic neuritis relapsed, again with raised inflammatory markers. He was started on azathioprine and prednisolone with good effect. A dual diagnosis of sarcoidosis and neuromyelitis optica with aquaporin-4 antibodies is very rare. Long-term immunosuppression is required. The case highlights the importance of identifying the features and cause of atypical optic neuritis.

Indexed as

HumansMaleMiddle AgedNeuromyelitis OpticaOptic NeuritisSarcoidosis

Identifiers

PMID34166585
PMCPMC8351381
OpenAlexW3174066261

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.