Evidence map›Paper›PMID 34166584›Full record

ReviewAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2021

Biomedical Implants with Charge-Transfer Monitoring and Regulating Abilities.

Donghui Wang, Ji Tan, Hongqin Zhu, Yongfeng Mei, Xuanyong Liu

Open access · goldAbstract readReview
In one paragraph

Review in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Potassium-Doped MnOACS nano · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Macrophages modulate stiffness-related foreign body responses through plasma membrane deformation.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  13. Review
  14. Article
  15. Functionalization of TiOMaterials (Basel, Switzerland) · 2022
    Review
  16. Review
  17. Biomedical Implants with Charge-Transfer Monitoring and Regulating Abilities.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Donghui WangState Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institutes of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, China.
Ji TanState Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institutes of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, China.
Hongqin ZhuState Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institutes of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, China.
Yongfeng MeiDepartment of Materials Science, Fudan University, Shanghai, 200433, China.ORCID 0000-0002-3314-6108
Xuanyong LiuState Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institutes of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, China.
Chinese Academy of Sciences · CNFudan University · CNHebei University of Technology · CN

Funding

National Key Research and Development Program of China 2017YFB0702600National Key Research and Development Program of China 2017YFB0702602National Natural Science Foundation of China 51831011National Natural Science Foundation of China 51901239National Natural Science Foundation of China 51961145108National Natural Science Foundation of China 61975035Program of Shanghai Academic Research Leader 19XD1400600Science and Technology Commission of Shanghai Municipality 18YF1426900Science and Technology Commission of Shanghai Municipality 19JC1415500
6 · The paper itself

Abstract

Transmembrane charge (ion/electron) transfer is essential for maintaining cellular homeostasis and is involved in many biological processes, from protein synthesis to embryonic development in organisms. Designing implant devices that can detect or regulate cellular transmembrane charge transfer is expected to sense and modulate the behaviors of host cells and tissues. Thus, charge transfer can be regarded as a bridge connecting living systems and human-made implantable devices. This review describes the mode and mechanism of charge transfer between organisms and nonliving materials, and summarizes the strategies to endow implants with charge-transfer regulating or monitoring abilities. Furthermore, three major charge-transfer controlling systems, including wired, self-activated, and stimuli-responsive biomedical implants, as well as the design principles and pivotal materials are systematically elaborated. The clinical challenges and the prospects for future development of these implant devices are also discussed.

Indexed as

Prostheses and ImplantsBiosensing TechniquesElectron TransportHumansbioelectronicsbiomedical implantcell behaviorcharge transferelectronion

Identifiers

PMID34166584
PMCPMC8373130
OpenAlexW3176994442

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.