Evidence map›Paper›PMID 34166580›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2021

Intravital Whole-Process Monitoring Thermo-Chemotherapy Via 2D Silicon Nanoplatform: A Macro Guidance and Long-Term Microscopic Precise Imaging Strategy.

Doudou Huang, Guangxing Wang, Jingsong Mao, Chunlei Liu, Zhongxiong Fan, Yunrui Zhang, Bei Zhang, Yang Zhao, Cuixia Dai, Yaqin He and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 2 countries.

Doudou HuangState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, 361102, China.
Guangxing WangState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, 361102, China.
Jingsong MaoDepartment of Radiology, Xiang'an Hospital of Xiamen University, Xiamen, 361102, China.
Chunlei LiuLaboratory of Translational Medicine, Medical Innovation Research Division of Chinese PLA General Hospital, Beijing, 100853, China.
Zhongxiong FanDepartment of Biomaterials, College of Materials, Research Center of Biomedical Engineering of Xiamen & Key Laboratory of Biomedical Engineering of Fujian Province & Fujian Provincial Key Laboratory for Soft Functional, Xiamen University, Xiamen, 361102, China.
Yunrui ZhangState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, 361102, China.
Bei ZhangState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, 361102, China.
Yang ZhaoDepartment of Mechanical and Electrical Engineering, Xiamen University, Xiamen, 361102, China.
Cuixia DaiCollege of Physics, Shanghai Institute of Technology, Shanghai, 201418, China.
Yaqin HeDepartment of Colorectal Surgery, General Hospital of Ningxia Medical University, Yinchuan, 750004, China.
Heng MaDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Fourth Military Medical University, Xi'an, 710032, China.
Gang LiuState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, 361102, China.
Xiaoyuan ChenYong Loo Lin School of Medicine and Faculty of Engineering, National University of Singapore, Singapore, 117597, Singapore.
Qingliang ZhaoState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, 361102, China.ORCID 0000-0003-2553-7413
Xiamen University · CNAir Force Medical University · CNChinese PLA General Hospital · CNNational University of Singapore · SGNingxia Medical University · CNShanghai Institute of Technology · CNShenzhen University · CN

Funding

National Science Foundation of China 61675134Natural Science Foundation of Guangdong Province 2021A1515011654Ningxia Science Foundation 2019AAC03255Scientific Research Foundation of State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics 2020KF002Scientific Research Foundation of State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics 2020KF004Shenzhen Bay Laboratory SZBL2019062801005Xiamen Science and Technology Plan Project 3502Z20183018
6 · The paper itself

Abstract

Tumor angiogenesis is a complex process that is unamenable to intravital whole-process monitoring, especially on microscopic assessment of tumor microvessel and quantifying microvascular hemodynamics before and after the nanotherapeutics, which hinder the understanding of nanotheranostics outcomes in tumor treatment. Herein, a new photoacoustic (PA) imaging-optical coherence tomography angiography (OCTA)-laser speckle (LS) multimodal imaging strategy is first proposed, which is not only able to precisely macro guide the thermo-chemotherapy of tumor by monitoring blood oxygen saturation (SaO

Indexed as

AnimalsAntimetabolites, AntineoplasticBrain NeoplasmsDisease Models, AnimalFluorouracilGliomaHumansMaleMiceMice, Inbred BALB CMultimodal ImagingNanostructuresOxygen SaturationPhotoacoustic TechniquesSiliconTomography, Optical CoherenceAntimetabolites, AntineoplasticFluorouracilSilicon2D silicon nanosheetsmicrovascular quantificationmultimodal optical imagingoptical coherence tomography angiographythermo-chemotherapy

Identifiers

PMID34166580
PMCPMC8373095
OpenAlexW3176524491

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.