Evidence map›Paper›PMID 34166549›Full record

ArticleClinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology2021

Effectiveness of lanadelumab for preventing hereditary angioedema attacks: Subgroup analyses from the HELP study.

Douglas T Johnston, Paula J Busse, Marc A Riedl, Marcus Maurer, John Anderson, Christina Nurse, Neil Inhaber, Ming Yu, Aleena Banerji, HELP Study Investigators

Open access · hybridAbstract readLetter
In one paragraph

Article in Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Long-term effectiveness and safety of lanadelumab in Canadian patients with hereditary angioedema: a subanalysis of the EMPOWER study.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2026
    Article
  6. Effectiveness of lanadelumab for preventing hereditary angioedema attacks: Subgroup analyses from the HELP study.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2021
    Article
  7. Angioedema and Fatty Acids.International journal of molecular sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 3 countries.

Douglas T JohnstonCarolina Asthma & Allergy Center, Charlotte, NC, USA.ORCID 0000-0003-0440-9789
Paula J BusseDivision of Clinical Immunology and Allergy, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Marc A RiedlDivision of Rheumatology, Allergy and Immunology, University of California San Diego, La Jolla, CA, USA.
Marcus MaurerDermatological Allergology, Allergie-Centrum-Charité, Department of Dermatology and Allergy, Charité - Universitätsmedizin Berlin, Berlin, Germany.ORCID 0000-0002-4121-481X
John AndersonAlabama Allergy & Asthma Center, Birmingham, AL, USA.
Christina NurseTakeda Pharmaceutical Company Limited, Lexington, MA, USA.
Neil InhaberTakeda Pharmaceutical Company Limited, Lexington, MA, USA.
Ming YuTakeda Pharmaceutical Company Limited, Lexington, MA, USA.
Aleena BanerjiDivision of Rheumatology, Allergy and Immunology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
HELP Study Investigators
Takeda (United States) · USAllergy, Asthma and Clinical Research Center · USAsthma and Allergy Specialists · USCharité - Universitätsmedizin Berlin · DEHarvard University · USIcahn School of Medicine at Mount Sinai · USLa Jolla Institute for Immunology · US

Funding

Shire Human Genetic Therapies, Inc., a Takeda company
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Angioedemas, HereditaryAntibodies, Monoclonal, HumanizedHumansQuality of LifeAntibodies, Monoclonal, Humanizedlanadelumab

Identifiers

PMID34166549
PMCPMC9290609
OpenAlexW3177215666

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.