Evidence map›Paper›PMID 34166507›Full record

ArticleBlood2021

The use of IV immunoglobulin in the treatment of vaccine-induced immune thrombotic thrombocytopenia.

Günalp Uzun, Karina Althaus, Anurag Singh, Peter Möller, Ulf Ziemann, Annerose Mengel, Peter Rosenberger, Martina Guthoff, Gabor C Petzold, Jens Müller and 10 more

Open access · bronzeAbstract readLetter
In one paragraph

Article in Blood, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
8.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Anti-Platelet factor 4 immunothrombosis-not just heparin and vaccine triggers.Research and practice in thrombosis and haemostasis · 2025
    Review
  4. Review
  5. Article
  6. How We Interpret Thrombosis with Thrombocytopenia Syndrome?International journal of molecular sciences · 2024
    Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Review
  18. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors at 8 institutions in 2 countries.

Günalp UzunCenter for Clinical Transfusion Medicine, Tuebingen, Germany.ORCID 0000-0002-8717-6230
Karina AlthausCenter for Clinical Transfusion Medicine, Tuebingen, Germany.
Anurag SinghInstitute for Clinical and Experimental Transfusion Medicine, Medical Faculty of Tuebingen, University Hospital of Tuebingen, Tuebingen, Germany.
Peter MöllerInstitute for Pathology, University Hospital of Ulm, Ulm, Germany.
Ulf ZiemannDepartment of Neurology & Stroke, Eberhard-Karls University, Tuebingen, Germany.ORCID 0000-0001-8372-3615
Annerose MengelDepartment of Neurology & Stroke, Eberhard-Karls University, Tuebingen, Germany.ORCID 0000-0002-2399-3020
Peter RosenbergerDepartment of Anaesthesiology and Intensive Care Medicine, University Hospital of Tuebingen, Tuebingen, Germany.
Martina GuthoffDepartment of Internal Medicine IV, Section of Nephrology and Hypertension, University Hospital of Tuebingen, Tuebingen, Germany.ORCID 0000-0002-4294-980X
Gabor C PetzoldDivision of Vascular Neurology and.ORCID 0000-0002-0145-8641
Jens MüllerInstitute for Experimental Hematology and Transfusion Medicine, University Hospital Bonn, Bonn, Germany.
Martin BüchselInstitute of Clinical Chemistry and Laboratory Medicine, Medical Centre-University of Freiburg, Freiburg im Breisgau, Germany.
Katharina FeilDepartment of Neurology & Stroke, Eberhard-Karls University, Tuebingen, Germany.ORCID 0000-0002-4566-712X
Hans HenkesDepartment of Neuroradiology, Klinikum Stuttgart, Stuttgart, Germany.ORCID 0000-0002-6534-036X
Nils HeyneDepartment of Internal Medicine IV, Section of Nephrology and Hypertension, University Hospital of Tuebingen, Tuebingen, Germany.
Matthias MaschkeDepartment of Neurology, Krankenhaus der Barmherzigen Brüder Trier, Trier, Germany.
Caroline LimpachDepartment of Neurology, Krankenhaus der Barmherzigen Brüder Trier, Trier, Germany.
Simon NagelDepartment of Neurology, University Hospital Heidelberg, Heidelberg, Germany.
Ulrich J SachsDepartment of Thrombosis and Hemostasis, Institute of Immunology and Transfusion Medicine, Giessen, Germany; and.ORCID 0000-0001-5486-5542
Falko FendInstitute for Pathology and Neuropathology, University Hospital of Tuebingen, Tuebingen, Germany.
Tamam BakchoulCenter for Clinical Transfusion Medicine, Tuebingen, Germany.
University of Tübingen · DEKrankenhaus der Barmherzigen Brüder Trier · DECenter for Vascular Biology Research · USHeidelberg University · DEKlinikum Stuttgart · DEUniversity Hospital Bonn · DEUniversity Hospital Ulm · DEUniversity of Freiburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AdultChAdOx1 nCoV-19Cohort StudiesCOVID-19FemaleHumansImmunoglobulins, IntravenousMaleMiddle AgedPlatelet CountPurpura, Thrombocytopenic, IdiopathicYoung AdultChAdOx1 nCoV-19Immunoglobulins, Intravenous

Identifiers

PMID34166507
PMCPMC8444699
OpenAlexW3177218481

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.