Evidence map›Paper›PMID 34166425›Full record

ArticlePloS one2021

Genetic characterization and phylogenetic analysis of porcine epidemic diarrhea virus in Guangdong, China, between 2018 and 2019.

Feng Wen, Jing Yang, Anqi Li, Zhonggui Gong, Lulu Yang, Qing Cheng, Congying Wang, Mengmeng Zhao, Sheng Yuan, Yao Chen and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed.

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  18. Characterization of anPathogens (Basel, Switzerland) · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Feng WenCollege of Life Science and Engineering, Foshan University, Foshan, Guangdong, China.ORCID 0000-0001-8790-1503
Jing YangCollege of Life Science and Engineering, Foshan University, Foshan, Guangdong, China.
Anqi LiCollege of Life Science and Engineering, Foshan University, Foshan, Guangdong, China.
Zhonggui GongCenter for Animal Disease Control and Prevention, Shaoguan, Guangdong, China.
Lulu YangCollege of Life Science and Engineering, Foshan University, Foshan, Guangdong, China.
Qing ChengCollege of Life Science and Engineering, Foshan University, Foshan, Guangdong, China.
Congying WangCollege of Life Science and Engineering, Foshan University, Foshan, Guangdong, China.
Mengmeng ZhaoCollege of Life Science and Engineering, Foshan University, Foshan, Guangdong, China.
Sheng YuanCollege of Life Science and Engineering, Foshan University, Foshan, Guangdong, China.
Yao ChenCollege of Life Science and Engineering, Foshan University, Foshan, Guangdong, China.
Saeed El-AshramCollege of Life Science and Engineering, Foshan University, Foshan, Guangdong, China.
Yong LiCollege of Animal Science and Technology, Jiangxi Agricultural University, Nanchang, Jiangxi, China.
Hai YuShanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, China.
Jinyue GuoCollege of Life Science and Engineering, Foshan University, Foshan, Guangdong, China.
Shujian HuangCollege of Life Science and Engineering, Foshan University, Foshan, Guangdong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Porcine epidemic diarrhea virus (PEDV), a leading cause of piglet diarrhea outbreaks, poses a significant danger to the swine industry. The aim of this study was to investigate the epidemic characteristics of PEDV that was circulating in Guangdong province, one of China's major pig producing provinces. Clinical samples were collected from eight pig farms in Guangdong province between 2018 and 2019 and tested for the major porcine enteric pathogens, including PEDV, transmissible gastroenteritis virus (TGEV), Swine enteric coronavirus (SeCoV), Swine acute diarrhea syndrome coronavirus (SADS-CoV), porcine deltacoronavirus (PDCoV), and porcine rotavirus (RV). As a result, only PEDV and RV were detected at a rate of 47.0% (16/34) and 18.6% (8/34), respectively. Coinfectoin with PEDV and RV occurred at a rate of PEDV 12.5% (2/16). Subsequently, the full-length S gene sequences of 13 PEDV strains were obtained, and phylogenetic analysis suggested the presence of GII-c group PEDV strains in this region (non-S-INDEL). Two novel common amino acid insertions (55T/IG56 and 551L) and one novel glycosylation site (1199G+) were detected when the CV777 and ZJ08 vaccine strains were compared. Furthermore, intragroup recombination events in the S gene regions 51-548 and 2478-4208 were observed in the PEDV strains studied. In summary, the observations provide current information on the incidence of viral agents causing swine diarrhea in southern China and detailed the genetic characteristics and evolutionary history of the dominant PEDV field strains. Our findings will aid in the development of an updated vaccine for the prevention and control of PEDV variant strains.

Indexed as

Disease OutbreaksPhylogenyAlphacoronavirusAnimalsChinaCoronavirus InfectionsPorcine epidemic diarrhea virusSwineSwine DiseasesTransmissible gastroenteritis virus

Identifiers

PMID34166425
PMCPMC8224968

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.