ArticlePLoS genetics2021
Genetics of white color and iridophoroma in "Lemon Frost" leopard geckos.
Article in PLoS genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 24 citations in OpenAlex.
- Dissecting cancer in a non-mammalian model: genomic insights from lemon frost geckos.BMC biology · 2026Article
- Localized oral histiocytic sarcoma in a leopard gecko (Eublepharis macularius).The Journal of veterinary medical science · 2026Article
- First report of an iridophoroma in a Tegu (Salvator merianae).BMC veterinary research · 2026Article
- Article
- Iridophoroma in Leopard Geckos (Eublepharis macularius): Clinical Complications and Histopathology.Journal of the American Association for Laboratory Animal Science : JAALAS · 2025Article
- Extraordinary model systems for regeneration.Development (Cambridge, England) · 2024Article
- The dynamic behavior of chromatophores marks the transition from bands to spots in leopard geckos.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Mechanisms Underlying the Formation and Evolution of Vertebrate Color Patterns.Annual review of genetics · 2023Review
- The revised reference genome of the leopard gecko (Eublepharis macularius) provides insight into the considerations of genome phasing and assembly.The Journal of heredity · 2023Article
- The revised reference genome of the leopard gecko (bioRxiv : the preprint server for biology · 2023Article
- A large deletion at the cortex locus eliminates butterfly wing patterning.G3 (Bethesda, Md.) · 2022Article
- Chromatophoromas in Reptiles.Veterinary sciences · 2022Review
- A community-science approach identifies genetic variants associated with three color morphs in ball pythons (Python regius).PloS one · 2022Article
- Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
The squamates (lizards and snakes) are close relatives of birds and mammals, with more than 10,000 described species that display extensive variation in a number of important biological traits, including coloration, venom production, and regeneration. Due to a lack of genomic tools, few genetic studies in squamates have been carried out. The leopard gecko, Eublepharis macularius, is a popular companion animal, and displays a variety of coloration patterns. We took advantage of a large breeding colony and used linkage analysis, synteny, and homozygosity mapping to investigate a spontaneous semi-dominant mutation, "Lemon Frost", that produces white coloration and causes skin tumors (iridophoroma). We localized the mutation to a single locus which contains a strong candidate gene, SPINT1, a tumor suppressor implicated in human skin cutaneous melanoma (SKCM) and over-proliferation of epithelial cells in mice and zebrafish. Our work establishes the leopard gecko as a tractable genetic system and suggests that a tumor suppressor in melanocytes in humans can also suppress tumor development in iridophores in lizards.
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