ArticleJournal of applied physiology (Bethesda, Md. : 1985)2021
Intraocular pressure and choroidal thickness respond differently to lower body negative pressure during spaceflight.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 45 citations in OpenAlex.
- Optic Nerve Vasculature and Countermeasure Assessment in a Bedrest Analogue of Spaceflight-Associated Neuro-Ocular Syndrome.American journal of ophthalmology · 2025Trial
- Decoding the space integrome: Personalized countermeasures for a mission to Mars.Experimental physiology · 2026Article
- Spaceflight-associated neuro-ocular syndrome (SANS): expert consensus on diagnosis and management.Eye (London, England) · 2026Review
- Integrative cardiovascular dose-response to graded lower-body negative pressure.Experimental physiology · 2025Article
- Analysis of Spaceflight-Associated Biometric and Refractive Changes in Astronauts.American journal of ophthalmology · 2025Article
- Influence of body position and time of day on ocular rhythms.Scientific reports · 2025Article
- Brains in space: impact of microgravity and cosmic radiation on the CNS during space exploration.Nature reviews. Neuroscience · 2025Review
- Spatial and Temporal Changes in Choroid Morphology Associated With Long-Duration Spaceflight.Investigative ophthalmology & visual science · 2025Article
- Spaceflight Associated Neuro-ocular Syndrome (SANS) and its countermeasures.Progress in retinal and eye research · 2025Review
- Self-Generated Lower Body Negative Pressure Exercise: A Low Power Countermeasure for Acute Space Missions.Life (Basel, Switzerland) · 2024Article
- Ocular perfusion pressure is not reduced in response to lower body negative pressure.NPJ microgravity · 2024Article
- Dynamic changes in perivascular space morphology predict signs of spaceflight-associated neuro-ocular syndrome in bed rest.NPJ microgravity · 2024Article
- Anatomical considerations for reducing ocular emergencies during spaceflight.Irish journal of medical science · 2024Review
- Correlation between choroidal thickness and the degree of myopia.Technology and health care : official journal of the European Society for Engineering and Medicine · 2024Article
- Effect of Different Postures on Intraocular Pressure in Open-Angle Glaucoma.Ophthalmology and therapy · 2024Article
- Ocular Deformations in Spaceflight-Associated Neuro-Ocular Syndrome and Idiopathic Intracranial Hypertension.Investigative ophthalmology & visual science · 2023Article
- MRI-based quantification of posterior ocular globe flattening during 60 days of strict 6° head-down tilt bed rest with and without daily centrifugation.Journal of applied physiology (Bethesda, Md. : 1985) · 2022Article
- Noninvasive indicators of intracranial pressure before, during, and after long-duration spaceflight.Journal of applied physiology (Bethesda, Md. : 1985) · 2022Article
- Gravitational Dose-Response Curves for Acute Cardiovascular Hemodynamics and Autonomic Responses in a Tilt Paradigm.Journal of the American Heart Association · 2022Article
- Future research directions to identify risks and mitigation strategies for neurostructural, ocular, and behavioral changes induced by human spaceflight: A NASA-ESA expert group consensus report.Frontiers in neural circuits · 2022Article
Corrections and comments
- Commented on by
Authors and funding
12 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Spaceflight-associated neuro-ocular syndrome (SANS) develops during long-duration (>1 mo) spaceflight presumably because of chronic exposure to a headward fluid shift that occurs in weightlessness. We aimed to determine whether reversing this headward fluid shift with acute application of lower body negative pressure (LBNP) can influence outcome measures at the eye. Intraocular pressure (IOP) and subfoveal choroidal thickness were therefore evaluated by tonometry and optical coherence tomography (OCT), respectively, in 14 International Space Station crewmembers before flight in the seated, supine, and 15° head-down tilt (HDT) postures and during spaceflight, without and with application of 25 mmHg LBNP. IOP in the preflight seated posture was 14.4 mmHg (95% CI, 13.5-15.2 mmHg), and spaceflight elevated this value by 1.3 mmHg (95% CI, 0.7-1.8 mmHg,
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.