Evidence map›Paper›PMID 34165903›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2021

Low Dose Soft X-Ray Remotely Triggered Lanthanide Nanovaccine for Deep Tissue CO Gas Release and Activation of Systemic Anti-Tumor Immunoresponse.

Youbin Li, Mingyang Jiang, Zhiming Deng, Songjun Zeng, Jianhua Hao

Open access · goldAbstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 55 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Review
  6. The Triple Crown: NO, CO, and HPharmacology & therapeutics · 2023
    Review
  7. Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 3 countries.

Youbin LiSynergetic Innovation Center for Quantum Effects and Application, Key Laboratory of Low-dimensional Quantum Structures and Quantum Control of Ministry of Education, Key Laboratory for Matter Microstructure and Function of Hunan Province, School of Physics and Electronics, Hunan Normal University, Changsha, 410081, P. R. China.
Mingyang JiangSynergetic Innovation Center for Quantum Effects and Application, Key Laboratory of Low-dimensional Quantum Structures and Quantum Control of Ministry of Education, Key Laboratory for Matter Microstructure and Function of Hunan Province, School of Physics and Electronics, Hunan Normal University, Changsha, 410081, P. R. China.
Zhiming DengSynergetic Innovation Center for Quantum Effects and Application, Key Laboratory of Low-dimensional Quantum Structures and Quantum Control of Ministry of Education, Key Laboratory for Matter Microstructure and Function of Hunan Province, School of Physics and Electronics, Hunan Normal University, Changsha, 410081, P. R. China.
Songjun ZengSynergetic Innovation Center for Quantum Effects and Application, Key Laboratory of Low-dimensional Quantum Structures and Quantum Control of Ministry of Education, Key Laboratory for Matter Microstructure and Function of Hunan Province, School of Physics and Electronics, Hunan Normal University, Changsha, 410081, P. R. China.
Jianhua HaoDepartment of Applied Physics, The Hong Kong Polytechnic University, Hong Kong, 999077, P. R. China.ORCID 0000-0002-6186-5169
Hunan Normal University · CNHong Kong Polytechnic University · HK

Funding

Furong Scholars Programme of Hunan ProvinceHunan Provincial Innovation Foundation for Postgraduate CX20190338National Natural Science Foundation of China 21671064Natural Science Foundation of Hunan Province, China 2019JJ10002Science and Technology Planning Project of Hunan Province 2017RS3031Scientific Research Fund of Hunan Provincial Education Department 19A329
6 · The paper itself

Abstract

Gas-based therapy has emerged as a new green therapy strategy for anti-tumor treatment. However, the therapeutic efficacy is still restricted by the deep tissue controlled release, poor lymphocytic infiltration, and inherent immunosuppressive tumor microenvironment (TME). Herein, a new type of nanovaccine is designed by integrating low dose soft X-ray-triggered CO releasing lanthanide scintillator nanoparticles (ScNPs: NaLuF

Indexed as

NanoparticlesAnimalsCancer VaccinesCarbon MonoxideCell Line, TumorCells, CulturedDisease Models, AnimalImmunogenic Cell DeathLanthanoid Series ElementsMiceNeoplasmsTumor MicroenvironmentX-RaysCancer VaccinesCarbon MonoxideLanthanoid Series Elementsactivated systemic anti-tumor immunotherapyelicited tumor oxidative stressgas therapylanthanide scintillator-based nanovaccinereversed immunosuppressive tumor microenvironmentsoft X-ray-activated CO release

Identifiers

PMID34165903
PMCPMC8224418
OpenAlexW3156887630

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.