Evidence map›Paper›PMID 34165900›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2021

Functionalized Mouth-Conformable Interfaces for pH Evaluation of the Oral Cavity.

Giusy Matzeu, Gili R S Naveh, Siddhart Agarwal, Jeffery A Roshko, Nicholas A Ostrovsky-Snider, Bradley S Napier, Fiorenzo G Omenetto

Open access · goldAbstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 41 citations in OpenAlex.

  1. Article
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  8. Review
  9. Functionalized Mouth-Conformable Interfaces for pH Evaluation of the Oral Cavity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Giusy MatzeuSilklab, Department of Biomedical Engineering, Tufts University, Medford, MA, 02155, USA.ORCID 0000-0002-5218-5866
Gili R S NavehHarvard School of Dental Medicine, 188 Longwood Avenue, Boston, MA, 02115, USA.
Siddhart AgarwalSilklab, Department of Biomedical Engineering, Tufts University, Medford, MA, 02155, USA.
Jeffery A RoshkoSilklab, Department of Biomedical Engineering, Tufts University, Medford, MA, 02155, USA.
Nicholas A Ostrovsky-SniderSilklab, Department of Biomedical Engineering, Tufts University, Medford, MA, 02155, USA.
Bradley S NapierSilklab, Department of Biomedical Engineering, Tufts University, Medford, MA, 02155, USA.
Fiorenzo G OmenettoSilklab, Department of Biomedical Engineering, Tufts University, Medford, MA, 02155, USA.ORCID 0000-0002-0327-853X
Tufts University · USHarvard University · US

Funding

Office of Naval Research N00014-19-1-2399U.S. Army Combat Capabilities Development Command W911QY-15-2-0001
6 · The paper itself

Abstract

Oral health monitoring is highly desired, especially for in home use, however, current methods are not sensitive enough and technically convoluted for this purpose. This paper presents incorporation of bioactive materials and colorimetric chemical sensors into routinely used oral appliances transforming them into bioresponsive, conformable interfaces. Specifically, endodontic paper points and dental floss can be functionalized to locally sense and monitor pH variations within the oral cavity via color changes. Moreover, edible colorimetric indicators are developed and used to make sensing, edible devices in the form factor of candies that can dynamically and visually respond to acidity changes in saliva. These interfaces would enable early detection of caries (e.g., using dental floss and paper points) providing low-cost point of care devices that respond in real-time by detecting pH variations in biological fluids thus bringing monitoring to home settings .

Indexed as

Oral HealthHumansHydrogen-Ion ConcentrationMouthOral HygieneSalivacolorimetric sensorsmouth compatible interfacesoral cavity

Identifiers

PMID34165900
PMCPMC8224410
OpenAlexW3138362286

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.