Evidence map›Paper›PMID 34165867›Full record

SynthesisBJOG : an international journal of obstetrics and gynaecology2021

Effectiveness of uterine tamponade devices for refractory postpartum haemorrhage after vaginal birth: a systematic review.

V Pingray, M Widmer, A Ciapponi, G J Hofmeyr, C Deneux, M Gülmezoglu, K Bloemenkamp, O T Oladapo, D Comandé, A Bardach and 3 more

Abstract readSystematic Review
In one paragraph

Synthesis in BJOG : an international journal of obstetrics and gynaecology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Suction tube uterine tamponade versus uterine balloon tamponade for treatment of refractory postpartum hemorrhage: A randomized clinical feasibility trial.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2025
    Trial
  4. Postpartum Hemorrhage: A Comprehensive Review of Medical and Surgical Treatment.Maternal-fetal medicine (Wolters Kluwer Health, Inc.) · 2026
    Review
  5. Article
  6. Achieving Equitable Access to Obstetric Devices Through Innovation, Improvisation and Off-Label Use.BJOG : an international journal of obstetrics and gynaecology · 2025
    Review
  7. Cost analysis of intrauterine balloon tamponade versus uterine artery embolization in the management of persistent postpartum hemorrhage.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2025
    Article
  8. Article
  9. Review
  10. Observational
  11. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

V PingrayInstituto de Efectividad Clínica y Sanitaria (IECS-CONICET), Buenos Aires, Argentina.ORCID 0000-0002-7889-2825
M WidmerUNDP-UNFPA-UNICEF-WHO-World Bank Special Program of Research, Development, and Research Training in Human Reproduction (HRP), Department of Sexual and Reproductive Health and Research, World Health Organization, Geneva, Switzerland.ORCID 0000-0002-4866-109X
A CiapponiInstituto de Efectividad Clínica y Sanitaria (IECS-CONICET), Buenos Aires, Argentina.ORCID 0000-0001-5142-6122
G J HofmeyrUniversity of Botswana, Gaborone, Botswana.ORCID 0000-0002-3080-1007
C DeneuxObstetrical Perinatal and Pediatric Epidemiology Research Team, EPOPé, INSERM, INRA, U1153 Centre for Epidemiology and Statistics Sorbonne Paris Cité (CRESS), Université de Paris, Paris, France.ORCID 0000-0002-6561-3321
M GülmezogluUNDP-UNFPA-UNICEF-WHO-World Bank Special Program of Research, Development, and Research Training in Human Reproduction (HRP), Department of Sexual and Reproductive Health and Research, World Health Organization, Geneva, Switzerland.ORCID 0000-0003-4674-0998
K BloemenkampDepartment of Obstetrics, Birth Centre Wilhelmina's Children Hospital, Division Woman and Baby, University Medical Center Utrecht, Utrecht, The Netherlands.
O T OladapoUNDP-UNFPA-UNICEF-WHO-World Bank Special Program of Research, Development, and Research Training in Human Reproduction (HRP), Department of Sexual and Reproductive Health and Research, World Health Organization, Geneva, Switzerland.
D ComandéInstituto de Efectividad Clínica y Sanitaria (IECS-CONICET), Buenos Aires, Argentina.
A BardachInstituto de Efectividad Clínica y Sanitaria (IECS-CONICET), Buenos Aires, Argentina.
P VázquezInstituto de Efectividad Clínica y Sanitaria (IECS-CONICET), Buenos Aires, Argentina.ORCID 0000-0003-0206-6452
G CormickInstituto de Efectividad Clínica y Sanitaria (IECS-CONICET), Buenos Aires, Argentina.
F AlthabeUNDP-UNFPA-UNICEF-WHO-World Bank Special Program of Research, Development, and Research Training in Human Reproduction (HRP), Department of Sexual and Reproductive Health and Research, World Health Organization, Geneva, Switzerland.ORCID 0000-0002-7024-8701

Funding

UNDPUNFPAUNICEFWHOWorld Bank Special Programme of Research, Development and Research Training in Human Reproduction, Department of Sexual and Reproductive Health and Research, WHOWorld Health Organization 001
6 · The paper itself

Abstract

objectivesTo evaluate uterine tamponade devices' effectiveness for atonic refractory postpartum haemorrhage (PPH) after vaginal birth and the effect of including them in institutional protocols. SEARCH STRATEGY: PubMed, EMBASE, CINAHL, LILACS, POPLINE, from inception to January 2021. STUDY SELECTION: Randomised and non-randomised comparative studies. OUTCOMES: Composite outcome including surgical interventions (artery ligations, compressive sutures or hysterectomy) or maternal death, and hysterectomy.

resultsAll included studies were at high risk of bias. The certainty of the evidence was rated as very low to low. One randomised study measured the effect of the condom-catheter balloon compared with standard care and found unclear results for the composite outcome (relative risk [RR] 2.33, 95% CI 0.76-7.14) and hysterectomy (RR 4.14, 95% CI 0.48-35.93). Three comparative studies assessed the effect of including uterine balloon tamponade in institutional protocols. A stepped wedge cluster randomised controlled trial suggested an increase in the composite outcome (RR 4.08, 95% CI 1.07-15.58) and unclear results for hysterectomy (RR 4.38, 95% CI 0.47-41.09) with the use of the condom-catheter or surgical glove balloon. One non-randomised study showed unclear effects on the composite outcome (RR 0.33, 95% CI 0.11-1.03) and hysterectomy (RR 0.49, 95% CI 0.04-5.38) after the inclusion of the Bakri balloon. The second non-randomised study found unclear effects on the composite outcome (RR 0.95, 95% CI 0.32-2.81) and hysterectomy (RR 1.84, 95% CI 0.44-7.69) after the inclusion of Ebb or Bakri balloon.

conclusionsThe effect of uterine tamponade devices for the management of atonic refractory PPH after vaginal delivery is unclear, as is the role of the type of device and the setting. TWEETABLE ABSTRACT: Unclear effects of uterine tamponade devices and their inclusion in institutional protocols for atonic refractory PPH after vaginal delivery.

Indexed as

AdultDelivery, ObstetricFemaleHemostatic TechniquesHumansHysterectomyLigationMaternal MortalityPostpartum HemorrhagePregnancyTreatment OutcomeUterine ArteryUterine Artery EmbolizationUterine Balloon TamponadeVaginaBakri ballooncondom uterine balloon tamponadehysterectomymaternal deathpostpartum haemorrhageuterine atonyvaginal delivery

Identifiers

PMID34165867
PMCPMC9292664

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.