ArticleAdvanced materials (Deerfield Beach, Fla.)2021
Expanding Biomaterial Surface Topographical Design Space through Natural Surface Reproduction.
Article in Advanced materials (Deerfield Beach, Fla.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 32 citations in OpenAlex.
- Multifunctional scaffold inspired by hepatocyte exosomes promotes bone regeneration by regulating osteogenic differentiation via PI3K/AKT pathway.Materials today. Bio · 2026Article
- Acquisition, quality control, and architecture of a large image dataset as a tool for in silico cell biological research.Materials today. Bio · 2025Article
- Combinatorial discovery of microtopographical landscapes that resist biofilm formation through quorum sensing mediated autolubrication.Nature communications · 2025Article
- Osteoblastic Differentiation and Mitigation of the Inflammatory Response in Titanium Alloys Decorated with Oligopeptides.Biomimetics (Basel, Switzerland) · 2025Article
- Superhydrophobicity Effects on Spheroid Formation and Polarization of Macrophages.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Spheroid Formation and Recovery Using Superhydrophobic Coating for Regenerative Purposes.Pharmaceutics · 2023Article
- Mechanobiology-informed biomaterial and tissue engineering strategies for influencing skeletal stem and progenitor cell fate.Frontiers in physiology · 2023Review
- Immunomodulatory biomaterials for implant-associated infections: from conventional to advanced therapeutic strategies.Biomaterials research · 2022Review
- Micro-Topographies Induce Epigenetic Reprogramming and Quiescence in Human Mesenchymal Stem Cells.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Small extracellular vesicles with nanomorphology memory promote osteogenesis.Bioactive materials · 2022Article
- Meniscus repair: up-to-date advances in stem cell-based therapy.Stem cell research & therapy · 2022Review
- Cells Dynamically Adapt to Surface Geometry by Remodeling Their Focal Adhesions and Actin Cytoskeleton.Frontiers in cell and developmental biology · 2022Article
- Bioactivated Oxidized Polyvinyl Alcohol towards Next-Generation Nerve Conduits Development.Polymers · 2021Article
- Expanding Biomaterial Surface Topographical Design Space through Natural Surface Reproduction.Advanced materials (Deerfield Beach, Fla.) · 2021Article
- Natural Architectures for Tissue Engineering and Regenerative Medicine.Journal of functional biomaterials · 2020Review
- Emerging titanium surface modifications: The war against polymicrobial infections on dental implants.Brazilian dental journalReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
Abstract
Surface topography is a tool to endow biomaterials with bioactive properties. However, the large number of possible designs makes it challenging to find the optimal surface structure to induce a specific cell response. The TopoChip platform is currently the largest collection of topographies with 2176 in silico designed microtopographies. Still, it is exploring only a small part of the design space due to design algorithm limitations and the surface engineering strategy. Inspired by the diversity of natural surfaces, it is assessed as to what extent the topographical design space and consequently the resulting cellular responses can be expanded using natural surfaces. To this end, 26 plant and insect surfaces are replicated in polystyrene and their surface properties are quantified using white light interferometry. Through machine-learning algorithms, it is demonstrated that natural surfaces extend the design space of the TopoChip, which coincides with distinct morphological and focal adhesion profiles in mesenchymal stem cells (MSCs) and Pseudomonas aeruginosa colonization. Furthermore, differentiation experiments reveal the strong potential of the holy lotus to improve osteogenesis in MSCs. In the future, the design algorithms will be trained with the results obtained by natural surface imprint experiments to explore the bioactive properties of novel surface topographies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.