Evidence map›Paper›PMID 34165769›Full record

ArticleMolecular biology reports2021

Rapamycin alleviates memory deficit against pentylenetetrazole-induced neural toxicity in Wistar male rats.

Fatemeh Aghaie, Afsaneh Shemshaki, Mojgan Rajabi, Parisa Khatami, Abdolkarim Hosseini

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular biology reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Fatemeh AghaieDepartment of Animal Sciences and Biotechnology, Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran, Iran.
Afsaneh ShemshakiDepartment of Exercise Physiology, Faculty of Physical Education and Sport Sciences, Al Zahra University, Tehran, Iran.
Mojgan RajabiDepartment of Physiology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Parisa KhatamiDepartment of Animal Sciences, Faculty of Biological Sciences, Islamic Azad University, North Tehran Branch, Tehran, Iran.
Abdolkarim HosseiniDepartment of Animal Sciences and Biotechnology, Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran, Iran. ab_hosseini@sbu.ac.ir.
Shahid Beheshti University · IRAlzahra University · IRIslamic Azad University North Tehran Branch · IRTabriz University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Numerous studies have reported that epilepsy causes memory deficits. The present study was aimed at studying the effect of rapamycin against the memory deficiency of the pentylenetetrazole (PTZ)-kindled animal model of epilepsy. In the present experiment, we randomly chose thirty male rats from the species of Wistar and categorized them in groups of control and experiment (6 for each group). The groups of experiment received the injection of rapamycin (0.5, 1 and 2 mg/kg) intraperitoneally (i.p.) and the group of control received normal saline (0.9%) treatment. Through the PTZ's sub-threshold dose (35 mg kg

Indexed as

AnimalsBrainDisease Models, AnimalKindling, NeurologicMaleMemoryMemory DisordersNeuronsPentylenetetrazoleRatsRats, WistarSeizuresSirolimusPentylenetetrazoleSirolimusGABA receptorKindlingPRAS40PTZRapamycin

Identifiers

PMID34165769
OpenAlexW3174652515

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.