Evidence map›Paper›PMID 34165766›Full record

SynthesisJournal of endocrinological investigation2022

Vitamin D supplementation and clinical outcomes in COVID-19: a systematic review and meta-analysis.

R Pal, M Banerjee, S K Bhadada, A J Shetty, B Singh, A Vyas

Registry-linked trialAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of endocrinological investigation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05415254 (A Randomized Open Label Study to Evaluate Efficacy of Calcitriol Supplementation in COVID-19 Patients With Vitamin D Deficiency), which is not on this map. Cited by 76 papers, 19 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
76citing papers in PubMed, 19 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05415254 naunknown statusnot on this map

A Randomized Open Label Study to Evaluate Efficacy of Calcitriol Supplementation in COVID-19 Patients With Vitamin D Deficiency

TypeinterventionalSponsorRenJi HospitalRan2022 to 2022Enrolled86ConditionsCOVID-19, Vitamin D DeficiencyArmsCalcitriol
3 · Its place in the literature

Who cites it

76 citing papers in PubMed, 19 syntheses or guidelines pooled it.

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  11. Does vitamin D supplementation reduce COVID-19 severity?: a systematic review.QJM : monthly journal of the Association of Physicians · 2022
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16 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

R Pal *Department of Endocrinology, Post Graduate Institute of Medical Education and Research, Chandigarh, 160012, India.
M Banerjee *Department of Endocrinology, Institute of Postgraduate Medical Education and Research, Kolkata, 700020, India.
S K BhadadaDepartment of Endocrinology, Post Graduate Institute of Medical Education and Research, Chandigarh, 160012, India. bhadadask@rediffmail.com.ORCID http://orcid.org/0000-0002-0410-8778
A J ShettyDepartment of Endocrinology, Post Graduate Institute of Medical Education and Research, Chandigarh, 160012, India.
B SinghGovernment Medical College, Patiala, 147001, India.
A VyasDepartment of Medicine, Rabindranath Tagore Medical College, Udaipur, 313001, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo provide a precise summary and collate the hitherto available clinical evidence on the effect of vitamin D supplementation on clinical outcomes in COVID-19 patients.

methodsPubMed/MEDLINE, Scopus, and Web of Science databases were systematically searched using appropriate keywords till June 8, 2021, to identify observational studies and randomized controlled trials (RCTs) reporting adverse clinical outcomes (ICU admission and/or mortality) in COVID-19 patients receiving vitamin D supplementation vs. those not receiving the same. Both prior use and use of vitamin D after COVID-19 diagnosis were considered. Unadjusted/adjusted pooled odds ratio (OR) with 95% confidence intervals (CI) were calculated (PROSPERO registration number CRD42021248488).

resultsWe identified 13 studies (10 observational, 3 RCTs) pooling data retrieved from 2933 COVID-19 patients. Pooled analysis of unadjusted data showed that vitamin D use in COVID-19 was significantly associated with reduced ICU admission/mortality (OR 0.41, 95% CI: 0.20, 0.81, p = 0.01, I

conclusionsVitamin D supplementation might be associated with improved clinical outcomes, especially when administered after the diagnosis of COVID-19. However, issues regarding the appropriate dose, duration, and mode of administration of vitamin D remain unanswered and need further research.

Indexed as

COVID-19 Drug TreatmentSARS-CoV-2Treatment OutcomeComorbidityCOVID-19Dietary SupplementsHumansIntensive Care UnitsOdds RatioVitamin DVitamin D DeficiencyVitamin DCOVID-19ICU admissionMortalityVitamin D

Identifiers

PMID34165766
PMCPMC8223190

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.