Comparison of the radiofrequency ablation versus laparoscopic adrenalectomy for aldosterone-producing adenoma: a meta-analysis of perioperative outcomes and safety.

Radiofrequency ablation (RFA) has emerged as a new treatment for primary aldosteronism owing to aldosterone-producing adenoma (APA). We aimed to compare the perioperative outcomes and safety of RFA and laparoscopic adrenalectomy (LA) for patients with APA. We searched PubMed, EMBASE, and the Cochrane Library for all literatures published from January 2001 to September 2020 to compare RFA with LA for APA. After data extraction and quality assessments, we used Review Manager 5.4.1 and STATA 14.0 to pool the data. Four retrospective studies consisting of 170 patients were obtained. Patients who underwent RFA were associated with shorter operative time (standard mean difference (SMD): -1.98, 95% confidence interval (CI): -3.86 to 0.11, P = 0.04), less intraoperative blood loss (SMD: -0.61, 95% CI: -0.96 to -0.26, P = 0.0007), and shorter hospital stay (weight mean difference (WMD): -1.40, 95% CI: -1.71 to -1.10, P < 0.00001) than those who underwent LA. No significant differences were found in the complication rate (odds ratio (OR): 0.67, 95% CI: 0.27-1.68, P = 0.39), the incidence of hypertensive crisis (OR: 3.16, 95% CI: 0.36-27.94, P = 0.30), the conversion rate (OR: 0.44, 95% CI: 0.04-4.32, P = 0.48) or the treatment success rate (OR: 0.72, 95% CI: 0.22-2.39, P = 0.59) between the two groups. RFA could achieve clinical outcomes that approach LA for patients with APA but result in shorter operative time, less intraoperative blood loss, and shorter hospital stay. However, RFA does not appear to be able to replace the LA. Future prospective randomized trials are needed to validate these results.