Evidence map›Paper›PMID 34165712›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2021

Pseudogenes as Competitive Endogenous RNAs: Target Prediction and Validation.

Florian A Karreth, Ugo Ala, Paolo Provero, Pier Paolo Pandolfi

Abstract read
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In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Florian A KarrethDepartment of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Ugo AlaDepartment of Veterinary Sciences, University of Turin, Turin, Italy.
Paolo ProveroDepartment of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center (MBC), University of Turin, Turin, Italy.
Pier Paolo PandolfiDepartment of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center (MBC), University of Turin, Turin, Italy. PierPaolo.PandolfiDeRinaldis@renown.org.

Funding

Deconstruction and in vivo functionalization of the ceRNA cancer network (PQ-11)R01CA170158 · NCI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI PANDOLFI, PIER PAOLO · 2012 to 2015
$1.4M
NCI NIH HHS R01 CA170158
6 · The paper itself

Abstract

Pseudogenes may regulate expression of their parental genes as well as other protein-coding genes through various mechanisms. One such mechanism is the ability to act as competitive endogenous RNA (ceRNA) and participate in microRNA-mediated cross-regulation. Here, we outline how to predict the targets of pseudogene ceRNAs bioinformatically and how to validate them experimentally.

Indexed as

3' Untranslated RegionsAnimalsCell LineComputational BiologyGene SilencingGenomicsHumansMicroRNAsPseudogenesRegulatory Sequences, Ribonucleic AcidRNA, MessengerRNA, Small InterferingTransfection3' Untranslated RegionsMicroRNAsRegulatory Sequences, Ribonucleic AcidRNA, MessengerRNA, Small Interfering3′UTRceRNAPredictionPseudogeneValidation

Identifiers

PMID34165712

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.