Evidence map›Paper›PMID 34165668›Full record

ArticleNeurochemical research2021

Nucleoprotein (P40) Binding to 5HT2C Receptors (5HT2CR) is the Key Point in the Pathogenesis of BoDV-1-Infected Hosts.

Yuanxin Li, Lixin Wang, Xueni Liu, Ying Huang, Xiaomei Li, Hong He, Xiaoyan Xu, Yujie Guo, Qi Li, Dan Zhu and 5 more

Abstract read
PubMed Publisher
In one paragraph

Article in Neurochemical research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 89% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 1 institution in 1 country.

Yuanxin Li *Faculty of Basic Medicine, Department of Pathology, Chongqing Medical University, 1 Yixueyuan Road, Yuzhong, Chongqing, 400016, China.
Lixin Wang *Faculty of Basic Medicine, Department of Pathology, Chongqing Medical University, 1 Yixueyuan Road, Yuzhong, Chongqing, 400016, China.
Xueni LiuFaculty of Basic Medicine, Department of Pathology, Chongqing Medical University, 1 Yixueyuan Road, Yuzhong, Chongqing, 400016, China.
Ying HuangFaculty of Basic Medicine, Department of Pathology, Chongqing Medical University, 1 Yixueyuan Road, Yuzhong, Chongqing, 400016, China.
Xiaomei LiFaculty of Basic Medicine, Department of Pathology, Chongqing Medical University, 1 Yixueyuan Road, Yuzhong, Chongqing, 400016, China.
Hong HeNHC Key Laboratory of Diagnosis and Treatment On Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, 1 Yixueyuan Road, Yuzhong, Chongqing, 400016, China.
Xiaoyan XuNHC Key Laboratory of Diagnosis and Treatment On Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, 1 Yixueyuan Road, Yuzhong, Chongqing, 400016, China.
Yujie GuoNHC Key Laboratory of Diagnosis and Treatment On Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, 1 Yixueyuan Road, Yuzhong, Chongqing, 400016, China.
Qi LiDepartment of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
Dan ZhuDepartment of Physical Examination, The First Affiliated Hospital of Chongqing Medical University, 1 Youyi Road, Yuzhong District, Chongqing, 400016, China.
Xingyu WangFaculty of Basic Medicine, Department of Pathology, Chongqing Medical University, 1 Yixueyuan Road, Yuzhong, Chongqing, 400016, China.
Haiyang WangNHC Key Laboratory of Diagnosis and Treatment On Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, 1 Yixueyuan Road, Yuzhong, Chongqing, 400016, China.
Wenwen LiFaculty of Basic Medicine, Department of Pathology, Chongqing Medical University, 1 Yixueyuan Road, Yuzhong, Chongqing, 400016, China.
Dan LiFaculty of Basic Medicine, Department of Pathology, Chongqing Medical University, 1 Yixueyuan Road, Yuzhong, Chongqing, 400016, China. lidancq@cqmu.edu.cn.ORCID http://orcid.org/0000-0001-9304-6451
Peng XieNHC Key Laboratory of Diagnosis and Treatment On Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, 1 Yixueyuan Road, Yuzhong, Chongqing, 400016, China. xiepeng@cqmu.edu.cn.
The Affiliated Yongchuan Hospital of Chongqing Medical University · CN

Funding

chongqing postdoctoral science fund project Grant No. cstc2019jcyj-bshX0090National Key Research & Development Program of China Grant No. 2016YFC1201700 and Grant No.2017YFA0505700scientific and technological research program of chongqing municipal education commission Grant No. KJQN202000432
6 · The paper itself

Abstract

Nucleoprotein (P40) is one of the most important proteins of Borna disease virus 1 (BoDV-1), but which proteins it would bind to in the pathogenesis of BoDV-1-infected hosts is unknown. We used lentivirus LV5-P40 overexpressing P40 to infect primary hippocampal neurons and characterized the interactome of P40 with co-immunoprecipitation (Co-IP) followed by mass spectrometry (MS) analysis. These interacting protein partners revealed the pathogenesis of BoDV-1-infected hosts. We also show for the first time that P40 interacts with 5HT2CR in rat neurons, which may be the molecular basis leading to neuropsychiatric diseases such as anxiety disorders and behavioral abnormalities after BoDV-1 infection of hosts.

Indexed as

AnimalsBorna DiseaseBorna disease virusEmbryo, MammalianFemaleHippocampusLentivirusNeuronsPregnancyProtein BindingRatsRats, Sprague-DawleyReceptor, Serotonin, 5-HT2CViral ProteinsHTR2C protein, humanp40 protein, Borna disease virusReceptor, Serotonin, 5-HT2CViral Proteins5HT2CRBorna disease virus 1InteractomeNeuropsychiatric diseasesP40

Identifiers

PMID34165668
OpenAlexW3175838719

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.