Evidence map›Paper›PMID 34165571›Full record

ArticleSleep2021

Neck fat and obstructive sleep apnea in obese adolescents.

Christopher M Cielo, Brendan T Keenan, Andrew Wiemken, Ignacio E Tapia, Andrea Kelly, Richard J Schwab

Open access · bronzeAbstract read
In one paragraph

Article in Sleep, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Review
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  4. Article
  5. Article
  6. A Systematic Review of Risk factors for Sleep Apnea.Preventive medicine reports · 2024
    Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. [Ultrasound measurement of upper airway related indicators and patients with obstructive sleep apnea hypopnea correlation study of disease severity].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Christopher M CieloDivision of Pulmonary & Sleep Medicine, Children's Hospital of Philadelphia.ORCID 0000-0001-5761-6373
Brendan T KeenanUniversity of Pennsylvania, Philadelphia, PA.ORCID 0000-0002-9070-847X
Andrew WiemkenUniversity of Pennsylvania, Philadelphia, PA.
Ignacio E TapiaDivision of Pulmonary & Sleep Medicine, Children's Hospital of Philadelphia.ORCID 0000-0003-1400-6852
Andrea KellyUniversity of Pennsylvania, Philadelphia, PA.ORCID 0000-0003-1724-9868
Richard J SchwabUniversity of Pennsylvania, Philadelphia, PA.
Children's Hospital of Philadelphia · USSleepMed · US

Funding

PATHOPHYSIOLOGY OF CHILDHOOD OBSTRUCTIVE SLEEP APNEAR01HL058585 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI MARCUS, CAROLE L · 1998 to 2012
$4.3M
Mechanisms of obstructive sleep apnea syndrome in infants with micrognathiaK23HL135346 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI CIELO, CHRISTOPHER MICHAEL · 2018 to 2021
$540k
NHLBI NIH HHS K23 HL135346NHLBI NIH HHS R01 HL058585NIH HHS NIH R01 HL058585
6 · The paper itself

Abstract

STUDY

objectivesIncreased neck circumference, a surrogate for the neck fat that can narrow the upper airway in obese individuals, is a risk factor for obstructive sleep apnea syndrome (OSAS) in adults, but the association between neck fat and OSAS in adolescent males and females is unknown. We hypothesized that obese adolescents with OSAS have more neck fat than controls, females more neck fat than males, and that neck fat correlates with obesity and OSAS severity.

methodsObese adolescents with OSAS and obese and normal-weight controls underwent upper airway magnetic resonance imaging, polysomnography, and anthropometrics, including neck circumference measurement. Intra-neck and subcutaneous neck fat measurements were manually segmented and compared among the three groups using ANOVA and between males and females using t-tests. The relationship between polysomnographic parameters and neck fat measurements was assessed in adolescents with OSAS using Pearson correlations.

resultsOne-hundred nineteen adolescents (38 females) were studied: 39 obese with OSAS, 34 obese controls, and 46 normal-weight controls. Neck fat was not greater in adolescents with OSAS compared to obese controls (p=0.35), and neck fat volume was not related to OSAS severity (p = 0.36). However, obese adolescents had more neck fat than normal-weight controls (p < 0.001), and neck fat volume correlated with neck circumference (r = 0.53, p < 0.001). Females had significantly greater cross-sectional neck fat than males (p < 0.001).

conclusionsWhile neck fat is associated with obesity and neck circumference in adolescents and is greater in females versus males, it does not appear to correlate with presence and severity of OSAS.

Indexed as

Pediatric ObesitySleep Apnea, ObstructiveAdolescentAdultCross-Sectional StudiesFemaleHumansMaleNeckPolysomnographyadiposityadolescentneck fatobesityobstructive sleep apnea

Identifiers

PMID34165571
PMCPMC8598172
OpenAlexW3177207521

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.