Evidence map›Paper›PMID 34165540›Full record

ArticleHuman molecular genetics2021

Genome-wide association study of body fat distribution traits in Hispanics/Latinos from the HCHS/SOL.

Anne E Justice, Kristin Young, Stephanie M Gogarten, Tamar Sofer, Misa Graff, Shelly Ann M Love, Yujie Wang, Yann C Klimentidis, Miguel Cruz, Xiuqing Guo and 23 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Human molecular genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Determinants of obesity in Latin America.Nature metabolism · 2024 · on this map
    Review
  7. Article
  8. Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

33 authors at 18 institutions in 4 countries.

Anne E JusticeDepartment of Population Health Sciences, Geisinger Health System, Danville, PA 17822, USA.ORCID 0000-0002-8903-8712
Kristin YoungDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27516, USA.
Stephanie M GogartenDepartment of Biostatistics, University of Washington, Seattle, WA 98195, USA.ORCID 0000-0002-7231-9745
Tamar SoferDepartment of Biostatistics, University of Washington, Seattle, WA 98195, USA.ORCID 0000-0001-8520-8860
Misa GraffDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27516, USA.
Shelly Ann M LoveDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27516, USA.
Yujie WangDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27516, USA.
Yann C KlimentidisDepartment of Epidemiology and Biostatistics, University of Arizona, Tucson, AZ 85724, USA.
Miguel CruzUnidad de Investigacion Medica en Bioquimica, Hospital de Especialidades, Centro Medico Nacional Siglo XXI (CMNSXX1)-IMSS, Mexico City 06720, Mexico.
Xiuqing GuoThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA 90502, USA.
Fernando HartwigCenter for Epidemiological Research, Universidade Federal de Pelotas, Pelotas 96020, Brazil.
Lauren PettyDivision of Genetic Medicine, Department of Medicine, Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Jie YaoThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA 90502, USA.
Matthew A AllisonDivision of Preventive Medicine, Department of Family Medicine, University of California San Diego, La Jolla, CA 92093, USA.
Jennifer E BelowDivision of Genetic Medicine, Department of Medicine, Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Thomas A BuchananDepartment of Medicine, Keck School of Medicine and Diabetes and Obesity Research Institute, University of Southern California, Los Angeles, CA 90033, USA.
Yii-Der Ida ChenThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA 90502, USA.
Mark O GoodarziDivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Craig HanisHuman Genetics Center, Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Heather M HighlandDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27516, USA.
Willa A HsuehDivision of Endocrinology, Diabetes and Metabolism, Department of Medicine, Wexner Medical Center, The Ohio State University, Columbus, OH 43210, USA.
Eli IppDepartment of Medicine, Endocrinology, Diabetes & Metabolism, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA 90502, USA.
Esteban ParraDepartment of Anthropology, University of Toronto at Mississauga, Mississauga, ON L5L 1C6, Canada.
Walter PalmasDepartment of Medicine, Columbia University Medical Center, New York, NY 10032, USA.
Leslie J RaffelDepartment of PediatrIcs, Division of Genetic and Genomic Medicine, University of California, Irvine, CA 92868, USA.
Jerome I RotterThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA 90502, USA.
Jingyi TanThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA 90502, USA.
Kent D TaylorThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA 90502, USA.
Adan ValladaresUnidad de Investigacion Medica en Bioquimica, Hospital de Especialidades, Centro Medico Nacional Siglo XXI (CMNSXX1)-IMSS, Mexico City 06720, Mexico.
Anny H XiangDepartment of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, CA 91101, USA.
Lisa Sánchez-JohnsenDepartment of Family Medicine, Rush University Medical Center, Chicago, IL 60612, USA.
Carmen R IsasiDepartment of Epidemiology & Population Health, Albert Einstein College of Medicine, Bronx, NY 10467, USA.
Kari E NorthDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27516, USA.
UCLA Medical Center · USUniversity of North Carolina at Chapel Hill · USCentro Medico Nacional Siglo XXI · MXUniversity of Washington · USVanderbilt University Medical Center · USAlbert Einstein College of Medicine · USCedars-Sinai Medical Center · USColumbia University Irving Medical Center · USKaiser Permanente · USRush University Medical Center · USThe Ohio State University Wexner Medical Center · USThe University of Texas Health Science Center at Houston · USUniversidade Federal de Pelotas · BRUniversity of Arizona · USUniversity of California, Irvine · USUniversity of California San Diego · USUniversity of Southern California · USUniversity of Toronto · CA

Funding

UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
Institute for Clinical and Translational Research (UL1)UL1RR025005 · NCRR · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2007 to 2011
$75.8M
Institute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1M
Wake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3M
Translational Research CoreP30DK020541 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI STREAMSON C CHUA · 2015 to 2026
$27.7M
Clinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2M
Genome-Wide Association Analysis in Essential Hypertension (FEHGAS study)R01HL086694 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ARAVINDA CHAKRAVARTI · 2007 to 2026
$21.2M
SUBCLINICAL CARDIOVASCULAR DISEASE COORDINATING CENTERN01HC95159 · NHLBI · UNIVERSITY OF WASHINGTON · PI KRONMAL, RICHARD A · 2007 to 2014
$19.6M
Hispanic Community Health Study - NIDCDN01HC65235 · NHLBI · YESHIVA UNIVERSITY · PI KAPLAN, ROBERT · 2007 to 2012
$16.0M
OTHER FUNCTIONS - R&D - HISPANIC COMMUNITY HEALTH STUDYN01HC65233 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI CAI, JAIWEN · 2007 to 2012
$15.1M
HISPANIC COMMUNITY HEALTH STUDY - FIELD CENTERN01HC65236 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI DIVIGLUS, MARTHA · 2007 to 2012
$13.4M
HISPANIC COMMUNITY HEALTH STUDY - FIELD CENTERN01HC65234 · NHLBI · UNIVERSITY OF MIAMI CORAL GABLES · PI SCHNEIDERMAN, NEIL · 2007 to 2012
$13.1M
CLC NIH HHS 75N90020D00002CLC NIH HHS 75N90020D00003NCATS NIH HHS UL1 TR000040NCATS NIH HHS UL1 TR001079NCATS NIH HHS UL1 TR001420NCATS NIH HHS UL1 TR001881NCI NIH HHS HHSN261201300004INCI NIH HHS HHSN261201300005INCRR NIH HHS UL1 RR025005NHGRI NIH HHS U01 HG004402NHLBI NIH HHS 75N92020C00001NHLBI NIH HHS 75N92020C00005NHLBI NIH HHS 75N92020C00006NHLBI NIH HHS 75N92020C00007NHLBI NIH HHS HHSN268201000001INHLBI NIH HHS HHSN268201000021CNHLBI NIH HHS HHSN268201000031CNHLBI NIH HHS HHSN268201100046CNHLBI NIH HHS HHSN268201300005CNHLBI NIH HHS HHSN268201500003INHLBI NIH HHS HHSN268201700001INHLBI NIH HHS HHSN268201700002INHLBI NIH HHS HHSN268201700003INHLBI NIH HHS HHSN268201700004INHLBI NIH HHS HHSN268201700005INHLBI NIH HHS K99 HL130580NHLBI NIH HHS N01HC65233NHLBI NIH HHS N01HC65234NHLBI NIH HHS N01HC65235NHLBI NIH HHS N01HC65236NHLBI NIH HHS N01HC65237NHLBI NIH HHS N01HC95159NHLBI NIH HHS N01HC95160NHLBI NIH HHS N01HC95161NHLBI NIH HHS N01HC95162NHLBI NIH HHS N01HC95163NHLBI NIH HHS N01HC95164NHLBI NIH HHS N01HC95165NHLBI NIH HHS N01HC95166NHLBI NIH HHS N01HC95167NHLBI NIH HHS N01HC95168NHLBI NIH HHS N01HC95169NHLBI NIH HHS P01 HL060030NHLBI NIH HHS R00 HL130580NHLBI NIH HHS R01 HL050050NHLBI NIH HHS R01 HL059367NHLBI NIH HHS R01 HL067974NHLBI NIH HHS R01 HL086694NHLBI NIH HHS R01 HL087641NHLBI NIH HHS R01 HL088457NHLBI NIH HHS R01 HL136528NHLBI NIH HHS R01 HL142302NHLBI NIH HHS R01 HL149683NHLBI NIH HHS T32 HL007055NHLBI NIH HHS T32 HL129982NIA NIH HHS HHSN271201100004CNIDA NIH HHS 75N95020D00004NIDDK NIH HHS P30 DK020541NIDDK NIH HHS R01 DK124097WHI NIH HHS HHSN268201100001CWHI NIH HHS HHSN268201100002CWHI NIH HHS HHSN268201100003CWHI NIH HHS HHSN268201100004C
6 · The paper itself

Abstract

Central obesity is a leading health concern with a great burden carried by ethnic minority populations, especially Hispanics/Latinos. Genetic factors contribute to the obesity burden overall and to inter-population differences. We aimed to identify the loci associated with central adiposity measured as waist-to-hip ratio (WHR), waist circumference (WC) and hip circumference (HIP) adjusted for body mass index (adjBMI) by using the Hispanic Community Health Study/Study of Latinos (HCHS/SOL); determine if differences in associations differ by background group within HCHS/SOL and determine whether previously reported associations generalize to HCHS/SOL. Our analyses included 7472 women and 5200 men of mainland (Mexican, Central and South American) and Caribbean (Puerto Rican, Cuban and Dominican) background residing in the USA. We performed genome-wide association analyses stratified and combined across sexes using linear mixed-model regression. We identified 16 variants for waist-to-hip ratio adjusted for body mass index (WHRadjBMI), 22 for waist circumference adjusted for body mass index (WCadjBMI) and 28 for hip circumference adjusted for body mass index (HIPadjBMI), which reached suggestive significance (P < 1 × 10-6). Many loci exhibited differences in strength of associations by ethnic background and sex. We brought a total of 66 variants forward for validation in cohorts (N = 34 161) with participants of Hispanic/Latino, African and European descent. We confirmed four novel loci (P < 0.05 and consistent direction of effect, and P < 5 × 10-8 after meta-analysis), including two for WHRadjBMI (rs13301996, rs79478137); one for WCadjBMI (rs3168072) and one for HIPadjBMI (rs28692724). Also, we generalized previously reported associations to HCHS/SOL, (8 for WHRadjBMI, 10 for WCadjBMI and 12 for HIPadjBMI). Our study highlights the importance of large-scale genomic studies in ancestrally diverse Hispanic/Latino populations for identifying and characterizing central obesity susceptibility that may be ancestry-specific.

Indexed as

Body Fat DistributionGenome-Wide Association StudyQuantitative Trait, HeritableAdiposityAllelesHispanic or LatinoHumansPolymorphism, Single Nucleotide

Identifiers

PMID34165540
PMCPMC8561424
OpenAlexW3175524359

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.