Evidence map›Paper›PMID 34165430›Full record

ArticleeLife2021

In silico analysis of the transcriptional regulatory logic of neuronal identity specification throughout the

Lori Glenwinkel, Seth R Taylor, Kasper Langebeck-Jensen, Laura Pereira, Molly B Reilly, Manasa Basavaraju, Ibnul Rafi, Eviatar Yemini, Roger Pocock, Nenad Sestan and 3 more

Abstract read
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
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  10. Hand Dissection of Caenorhabditis elegans Intestines.Journal of visualized experiments : JoVE · 2022
    Article
  11. Article
  12. Article
  13. Article
  14. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Lori GlenwinkelDepartment of Biological Sciences, Columbia University, Howard Hughes Medical Institute, New York, United States.ORCID 0000-0003-4874-6146
Seth R TaylorDepartment of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, United States.
Kasper Langebeck-JensenBiotech Research and Innovation Centre, University of Copenhagen, Copenhagen, Denmark.
Laura PereiraDepartment of Biological Sciences, Columbia University, Howard Hughes Medical Institute, New York, United States.
Molly B ReillyDepartment of Biological Sciences, Columbia University, Howard Hughes Medical Institute, New York, United States.ORCID 0000-0002-7180-7763
Manasa BasavarajuDepartment of Neurobiology, Yale University School of Medicine, New Haven, United States.
Ibnul RafiDepartment of Biological Sciences, Columbia University, Howard Hughes Medical Institute, New York, United States.
Eviatar YeminiDepartment of Biological Sciences, Columbia University, Howard Hughes Medical Institute, New York, United States.
Roger PocockBiotech Research and Innovation Centre, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-5515-3608
Nenad SestanDepartment of Neurobiology, Yale University School of Medicine, New Haven, United States.ORCID 0000-0003-0966-9619
Marc HammarlundDepartment of Neurobiology, Yale University School of Medicine, New Haven, United States.
David M MillerDepartment of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, United States.ORCID 0000-0001-9048-873X
Oliver HobertDepartment of Biological Sciences, Columbia University, Howard Hughes Medical Institute, New York, United States.ORCID 0000-0002-7634-2854

Funding

Discovery and analysis of the C. elegans neuronal gene expression network (CENGEN)R01NS100547 · NINDS · YALE UNIVERSITY · PI MARC HAMMARLUND, Oliver Hobert · 2017 to 2026
$11.2M
Hormones: Molecular Mechanism of Action and FunctionsT32DK007328 · NIDDK · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI KOUSTENI, STAVROULA · 1986 to 2025
$7.8M
Howard Hughes Medical InstituteNIDDK NIH HHS T32 DK007328NINDS NIH HHS R01 NS100547
6 · The paper itself

Abstract

The generation of the enormous diversity of neuronal cell types in a differentiating nervous system entails the activation of neuron type-specific gene batteries. To examine the regulatory logic that controls the expression of neuron type-specific gene batteries, we interrogate single cell expression profiles of all 118 neuron classes of the

Indexed as

Cell DifferentiationGene Expression Regulation, DevelopmentalAnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsComputer SimulationNervous SystemNeuronsTranscription FactorsCaenorhabditis elegans ProteinsTranscription FactorsC. eleganscis-regulatory analysisneuronal differentiationneurosciencetranscription factor

Identifiers

PMID34165430
PMCPMC8225391

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.