Evidence map›Paper›PMID 34165361›Full record

ArticleMultiple sclerosis (Houndmills, Basingstoke, England)2021

Autoimmune glomerulonephritis in a multiple sclerosis patient after cladribine treatment.

Kristina Schönfelder, Helene Schuh, Frederick Pfister, Julia Krämer, Ute Eisenberger, Jelena Skuljec, Jana Hackert, Tobias Ruck, Steffen Pfeuffer, Michael Fleischer and 6 more

Open access · hybridAbstract readCase Reports
In one paragraph

Article in Multiple sclerosis (Houndmills, Basingstoke, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
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  5. Review
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  8. Multiple Sclerosis: Switching from Natalizumab to Other High-Efficacy Treatments to Mitigate Progressive Multifocal Leukoencephalopathy Risk.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 1 country.

Kristina SchönfelderDepartment of Nephrology, University Medicine Essen, Essen, Germany Center for Translational Neuro- and Behavioral Sciences, University Hospital Essen, Essen, Germany.
Helene SchuhDepartment of Neurology, University Medicine Essen, Essen, Germany/Center for Translational Neuro- and Behavioral Sciences, University Hospital Essen, Essen, Germany.
Frederick PfisterDepartment of Nephropathology, University Medicine Erlangen, Erlangen, Germany.
Julia KrämerDepartment of Neurology with Institute of Translational Neurology, University Hospital Münster, Münster, Germany.
Ute EisenbergerDepartment of Nephrology, University Medicine Essen, Essen, Germany Center for Translational Neuro- and Behavioral Sciences, University Hospital Essen, Essen, Germany.
Jelena SkuljecDepartment of Neurology, University Medicine Essen, Essen, Germany/Center for Translational Neuro- and Behavioral Sciences, University Hospital Essen, Essen, Germany.
Jana HackertDepartment of Neurology, University Medicine Essen, Essen, Germany/Center for Translational Neuro- and Behavioral Sciences, University Hospital Essen, Essen, Germany.
Tobias RuckDepartment of Neurology with Institute of Translational Neurology, University Hospital Münster, Münster, Germany.
Steffen PfeufferDepartment of Neurology with Institute of Translational Neurology, University Hospital Münster, Münster, Germany.ORCID 0000-0001-5171-4845
Michael FleischerDepartment of Neurology, University Medicine Essen, Essen, Germany/Center for Translational Neuro- and Behavioral Sciences, University Hospital Essen, Essen, Germany.
Anja GäcklerDepartment of Nephrology, University Medicine Essen, Essen, Germany Center for Translational Neuro- and Behavioral Sciences, University Hospital Essen, Essen, Germany.
Tim HagenackerDepartment of Neurology, University Medicine Essen, Essen, Germany/Center for Translational Neuro- and Behavioral Sciences, University Hospital Essen, Essen, Germany.
Andreas KribbenDepartment of Nephrology, University Medicine Essen, Essen, Germany Center for Translational Neuro- and Behavioral Sciences, University Hospital Essen, Essen, Germany.
Sven G MeuthDepartment of Neurology with Institute of Translational Neurology, University Hospital Münster, Münster, Germany.
Christoph KleinschnitzDepartment of Neurology, University Medicine Essen, Essen, Germany/Center for Translational Neuro- and Behavioral Sciences, University Hospital Essen, Essen, Germany.
Refik PulDepartment of Neurology, University Medicine Essen, Essen, Germany/Center for Translational Neuro- and Behavioral Sciences, University Hospital Essen, Essen, Germany.
Essen University Hospital · DEUniversity Hospital Münster · DEUniversitätsklinikum Erlangen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOral cladribine is an approved disease-modifying drug for the treatment of relapsing multiple sclerosis. In controlled clinical trials as well as in post marketing safety assessments, autoimmune conditions have not yet been reported as a specific side effect of cladribine. OBJECTIVE AND

resultsHere, we report a case of anti-glomerular basement membrane antibody-mediated glomerulonephritis that occurred shortly after the fourth cladribine treatment cycle.

conclusionNeurologists should be attentive to the development of secondary autoimmunity in cladribine-treated patients.

Indexed as

GlomerulonephritisMultiple SclerosisMultiple Sclerosis, Relapsing-RemittingCladribineHumansImmunosuppressive AgentsNeoplasm Recurrence, LocalCladribineImmunosuppressive Agentsadverse eventanti-glomerular basement membrane antibodiesautoimmune hepatitiscladribine tabletsRelapsing multiple sclerosissecondary autoimmunitythrombocytopenia

Identifiers

PMID34165361
PMCPMC8521349
OpenAlexW3173550525

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.