Evidence map›Paper›PMID 34165357›Full record

ArticleCartilage2021

Health-Related Quality of Life in Ankle Osteoarthritis: A Case-Control Study.

Liam D A Paget, Johannes L Tol, Gino M M J Kerkhoffs, Gustaaf Reurink

Registry-linked trialOpen access · hybridAbstract read
In one paragraph

Article in Cartilage, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07732153 (Survival, Clinical and Radiological Outcomes of Total Ankle Arthroplasty With Lateral Transfibular Approach With a Minimum 10 Years Follow up), which is not on this map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07732153 active not recruitingnot on this mapstarted 2026, after this paper: background citation

Survival, Clinical and Radiological Outcomes of Total Ankle Arthroplasty With Lateral Transfibular Approach With a Minimum 10 Years Follow up

Typeobservational_patient_registrySponsorI.R.C.C.S Ospedale Galeazzi-Sant'AmbrogioRan2026 to 2026Enrolled61ConditionsTotal Ankle Arthroplasty Surviviorship
3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Ankle osteoarthritis: Toward new understanding and opportunities for prevention and intervention.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2024
    Review
  9. Article
  10. Article
  11. Article
  12. Non-invasive brain stimulation for osteoarthritis.Frontiers in aging neuroscience · 2022
    Review
  13. The ankle cartilage cascade: incremental cartilage damage in the ankle joint.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Liam D A PagetAmsterdam UMC, University of Amsterdam, Department of Orthopaedic Surgery, Amsterdam Movement Sciences, Amsterdam, The Netherlands.ORCID 0000-0002-0062-9701
Johannes L TolAcademic Center for Evidence-Based Sports Medicine (ACES), Amsterdam, The Netherlands.
Gino M M J KerkhoffsAmsterdam UMC, University of Amsterdam, Department of Orthopaedic Surgery, Amsterdam Movement Sciences, Amsterdam, The Netherlands.
Gustaaf ReurinkAmsterdam UMC, University of Amsterdam, Department of Orthopaedic Surgery, Amsterdam Movement Sciences, Amsterdam, The Netherlands.
Academic Center for Evidence-Based Sports Medicine · NLQatar Orthopaedic and Sports Medicine Hospital · QA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveAnkle osteoarthritis (OA) has a prevalence of 3.4% in the general population of which 70% to 78% is posttraumatic, affecting younger patients with a longer projected life span compared with hip and knee OA. The current literature reports the physical and mental quality of life (QoL) of patients with ankle OA, to be similar to end-stage hip OA, end-stage kidney disease and digestive heart failure. However, the QoL of ankle OA patients has not yet been determined compared with a matched control group representing the general population. Our aim is to determine the physical and mental QoL compared with a matched control group.

designThe Physical and Mental Component Summaries of the Short Form-36 of 100 patients with ankle OA were compared with 91 age- and gender-matched controls. This case-control study is a substudy of the PRIMA trial, in which the efficacy of platelet-rich plasma injections for ankle OA is determined.

resultsA clinically relevant difference was found for both the Physical (

conclusionsPatients with ankle OA had a clinically relevant poorer mental and physical QoL compared with matched controls from the general population. Furthermore, the physical QoL of patients with ankle OA from younger age categories was affected more than those in older age categories.

Indexed as

Ankle JointQuality of LifeAdolescentAdultAgedCase-Control StudiesFemaleHumansMaleMiddle AgedNetherlandsOsteoarthritisSickness Impact Profileankleautologous bloodgraftsintra-articular deliveryosteoarthritis

Identifiers

PMID34165357
PMCPMC8808799
OpenAlexW3173913780

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.