Evidence map›Paper›PMID 34165350›Full record

ReviewThe journal of histochemistry and cytochemistry : official journal of the Histochemistry Society2022

AmotL2, IQGAP1, and FKBP51 Scaffold Proteins in Glioblastoma Stem Cell Niches.

Deborah Rotoli, Lucio Díaz-Flores, Ricardo Gutiérrez, Manuel Morales, Julio Ávila, Pablo Martín-Vasallo

Open access · bronzeAbstract readReview
In one paragraph

Review in The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Role of scaffold proteins in the heterogeneity of glioblastoma.Cell communication and signaling : CCS · 2024
    Review
  5. Article
  6. Article
  7. Article
  8. Cell Biology Meets Cell Metabolism: Energy Production Is Similar in Stem Cells and in Cancer Stem Cells in Brain and Bone Marrow.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2022
    Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Deborah RotoliDepartment of Bioquímica, Microbiología, Biología Celular y Genética, Universidad de La Laguna, San Cristóbal de La Laguna, Spain.
Lucio Díaz-FloresDepartment of Basic Medical Sciences and Department of Anatomy, Pathology, Histology and Radiology, Universidad de La Laguna, San Cristóbal de La Laguna, Spain.
Ricardo GutiérrezDepartment of Basic Medical Sciences and Department of Anatomy, Pathology, Histology and Radiology, Universidad de La Laguna, San Cristóbal de La Laguna, Spain.
Manuel MoralesOncología Médica, Hospital Universitario Nuestra Señora de Candelaria, Santa Cruz de Tenerife, Spain.
Julio ÁvilaDepartment of Bioquímica, Microbiología, Biología Celular y Genética, Universidad de La Laguna, San Cristóbal de La Laguna, Spain.
Pablo Martín-VasalloDepartment of Bioquímica, Microbiología, Biología Celular y Genética, Universidad de La Laguna, San Cristóbal de La Laguna, Spain.
Universidad de La Laguna · ESHospital Universitario Nuestra Señora de Candelaria · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glioma stem cells (GSCs) live in a continuous process of stemness reprogramming to achieve specific cell commitment within the so-called GSC niches, specifically located in periarteriolar regions. In this review, we analyze the expression levels, cellular and subcellular location, and role of three scaffold proteins (IQGAP1, FKBP51, and AmotL2) in GSC niches. Scaffold proteins contribute to cell differentiation, migration, and angiogenesis in glioblastoma. It could be of diagnostic interest for establishing stages, for therapeutic targets, and for improving glioblastoma prognosis, which is still at the experimental level.

Indexed as

AngiomotinsCell DifferentiationGlioblastomaHumansNeoplastic Stem Cellsras GTPase-Activating ProteinsTacrolimus Binding Protein 5Tacrolimus Binding ProteinsAMOTL2 protein, humanAngiomotinsIQ motif containing GTPase activating protein 1ras GTPase-Activating ProteinsTacrolimus Binding Protein 5Tacrolimus Binding ProteinsAmotL2and FKBP51angiogenesisglioblastoma stem cellsIQGAP1scaffold proteinsstem cell nichestemnesstumor heterogeneitytumor immune infiltratetumor microenvironment

Identifiers

PMID34165350
PMCPMC8721575
OpenAlexW3174966213

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.