Evidence map›Paper›PMID 34165344›Full record

ReviewExperimental biology and medicine (Maywood, N.J.)2021

Interspecies chimeras as a platform for exogenic organ production and transplantation.

Daniel J Garry, Mary G Garry

Abstract readReview
In one paragraph

Review in Experimental biology and medicine (Maywood, N.J.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Blastocyst complementation and interspecies chimeras in gene edited pigs.Frontiers in cell and developmental biology · 2022
    Review
  3. Introduction to the Regenerative Medicine Thematic Issue.Experimental biology and medicine (Maywood, N.J.) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Daniel J GarryLillehei Heart Institute, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0002-8970-7365
Mary G GarryLillehei Heart Institute, University of Minnesota, Minneapolis, MN 55455, USA.

Funding

Bioengineering Strategies for Cardiovascular DiseaseR01HL144582 · NHLBI · UNIVERSITY OF MINNESOTA · PI GARRY, DANIEL J. · 2019 to 2022
$3.1M
NHLBI NIH HHS R01 HL144582
6 · The paper itself

Abstract

Chronic diseases are associated with considerable morbidity and mortality. Therefore, new therapeutic strategies are warranted. Here, we provide a brief review outlining the rationale and feasibility for the generation of intraspecies and interspecies chimeras, which one day may serve as a platform for organ transplantation. These strategies are further associated with consideration of scientific and ethical issues.

Indexed as

Gene EditingAnimalsCell TransplantationChimeraHumansModels, AnimalMuscle, SkeletalPluripotent Stem CellsChimeraETV2hiPSCsMYF5MYF6MYODsomatic cell nuclear transfer

Identifiers

PMID34165344
PMCPMC8381704

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.