Evidence map›Paper›PMID 34165324›Full record

ArticleJournal of clinical microbiology2021

Manual Reading of Sensititre Broth Microdilution System Panels Improves Accuracy of Susceptibility Reporting for Polymyxin Antibiotics.

Michelle M Bellerose, Andrew E Clark, Jung-Ho Youn, Rebecca A Weingarten, Chelsea M Crooks, John P Dekker, Karen M Frank

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.1field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Michelle M Bellerose *Department of Laboratory Medicine, National Institutes of Health Clinical Centergrid.410305.3, Bethesda, Maryland, USA.
Andrew E Clark *Department of Laboratory Medicine, National Institutes of Health Clinical Centergrid.410305.3, Bethesda, Maryland, USA.
Jung-Ho YounDepartment of Laboratory Medicine, National Institutes of Health Clinical Centergrid.410305.3, Bethesda, Maryland, USA.
Rebecca A WeingartenDepartment of Laboratory Medicine, National Institutes of Health Clinical Centergrid.410305.3, Bethesda, Maryland, USA.
Chelsea M CrooksDepartment of Laboratory Medicine, National Institutes of Health Clinical Centergrid.410305.3, Bethesda, Maryland, USA.
John P DekkerDepartment of Laboratory Medicine, National Institutes of Health Clinical Centergrid.410305.3, Bethesda, Maryland, USA.
Karen M FrankDepartment of Laboratory Medicine, National Institutes of Health Clinical Centergrid.410305.3, Bethesda, Maryland, USA.
National Institutes of Health Clinical Center · USNational Institutes of Health · US

Funding

Application of Genomic Approaches to Bacterial Pathogenesis and Mechanisms of Antimicrobial ResistanceZIAAI001249 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI DEKKER, JOHN · 2019 to 2025
$13.7M
Intramural NIH HHS
6 · The paper itself

Abstract

Accurate and reproducible antimicrobial susceptibility testing (AST) of polymyxin antibiotics is critical, as these drugs are last-line therapeutic options for the treatment of multidrug-resistant Gram-negative bacterial infections. However, polymyxin AST in the routine laboratory remains challenging. In this study, we evaluated the performance of an automated broth microdilution (BMD) system (Sensititre, ThermoFisher) compared to that of agar dilution (AD) for colistin and polymyxin B AST of 129

Indexed as

ColistinReadingAnti-Bacterial AgentsHumansMicrobial Sensitivity TestsPolymyxin BAnti-Bacterial AgentsColistinPolymyxin Bassayclinical methodscolistindiagnosticGram-negative bacteriapolymyxin Bpolymyxinssusceptibility

Identifiers

PMID34165324
PMCPMC8373007
OpenAlexW3173969820

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.