Evidence map›Paper›PMID 34165263›Full record

SynthesisArthritis care & research2022

Rehabilitation Interventions in Systemic Sclerosis: A Systematic Review and Future Directions.

Susan L Murphy, Janet L Poole, Yen T Chen, Alain Lescoat, Dinesh Khanna

Registry-linked trialOpen access · bronzeAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Arthritis care & research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05821335 (The Development and Investigation of Effectiveness of Leap Motion Based Gamefication Exercises in Hand Rehabilitation of the Individuals With Systemic Sclerosis), which is not on this map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05821335 naunknown statusnot on this mapstarted 2023, after this paper: background citation

The Development and Investigation of Effectiveness of Leap Motion Based Gamefication Exercises in Hand Rehabilitation of the Individuals With Systemic Sclerosis

TypeinterventionalSponsorIstanbul UniversityRan2023 to 2024Enrolled32ConditionsRheumatology, Scleroderma, Systemic, Video Games, PhysiotherapyArmsLeap motion assisted rehabilitation, Traditional program
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Susan L MurphyUniversity of Michigan and VA Ann Arbor Healthcare System, Ann Arbor, Michigan.ORCID 0000-0001-7924-0012
Janet L PooleUniversity of New Mexico, Albuquerque.ORCID 0000-0003-3093-5707
Yen T ChenUniversity of Michigan, Ann Arbor.ORCID 0000-0001-7723-6431
Alain LescoatUniversity of Michigan, Ann Arbor, and Rennes University Hospital and Univ Rennes, CHU Rennes, Inserm, EHESP, Irset (Institut de Recherche en Santé, Environnement et Travail) - UMR_S 1085, Rennes, France.ORCID 0000-0003-2081-8558
Dinesh KhannaUniversity of Michigan, Ann Arbor.ORCID 0000-0003-1412-4453
University of Michigan · USInserm · FRUniversity of New Mexico · US

Funding

Outcomes Research in Rheumatic DiseasesK24AR063120 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KHANNA, DINESH · 2012 to 2022
$1.6M
Systemic Sclerosis-Associated Interstitial Lung Disease Response IndexR01AR070470 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KHANNA, DINESH · 2017 to 2019
$642k
Syk blockade in bullous skin diseasesR43AR063129 · NIAMS · PORTOLA PHARMACEUTICALS, INC. · PI SINHA, UMA · 2012 to 2012
$298k
ACL HHS 90ARCP0003French network of the University Hospitals HUGO AAP-GIRCI JCM2020NIAMS NIH HHS K24 AR063120NIAMS NIH HHS K24-AR-063129NIAMS NIH HHS R01 AR070470NIAMS NIH HHS R43 AR063129Rennes University Hospital CORECT Visiting Grant 2020
6 · The paper itself

Abstract

objectiveTo systematically review evidence of rehabilitation interventions for improving outcomes in systemic sclerosis (SSc) and to evaluate evidence quality.

methodsSeveral electronic databases were searched to identify studies in which rehabilitation professionals delivered, supervised, or participated in interventions for individuals with SSc. Randomized controlled trials (RCTs) or non-randomized trials, one-arm trials, and prospective quasi-experimental studies with interventions were included if they had ≥10 participants. Quality appraisal was conducted by 2 independent raters using the Physiotherapy Evidence Database (PEDro) Scale.

resultsA total of 16 good or excellent quality studies (15 RCTs, 1 prospective quasi-experimental study) were included. Most rehabilitation interventions focused on hands/upper extremities, followed by multicomponent, orofacial, and directed self-management. Sample sizes varied between 20-267 participants (median 38). In 50% of studies, participants in intervention groups significantly improved compared to controls. Most studies demonstrated within-group improvements in intervention groups. Interventions varied in content, delivery, length, and dose and outcome measures collected.

conclusionExisting evidence provides some support for rehabilitation in SSc, such as interventions that focus on hand and upper extremity outcomes or are multicomponent, although there is high study heterogeneity. The evidence base would benefit from interventions testing similar replicable components, use of common outcome measures, and incorporation of delivery modes that enable larger sample sizes. There are challenges in recruiting participants due to the rarity of SSc and high disease burden, as participants' involvement in rehabilitation studies requires active participation over time. Intervention studies designed to reduce participation barriers may facilitate translation of effective interventions into practice.

Indexed as

HumansPhysical Therapy ModalitiesScleroderma, Systemic

Identifiers

PMID34165263
PMCPMC8695630
OpenAlexW3176193355

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.