Evidence map›Paper›PMID 34165180›Full record

Trial reportCardiology journal2023

Clinical characteristics and outcomes of patients with takotsubo syndrome versus spontaneous coronary artery dissection.

Victoria L Cammann, Annahita Sarcon, Konrad A Szawan, Michael Würdinger, Saif Azam, Jerold Shinbane, Burkhardt Seifert, Jelena R Ghadri, Jacqueline Saw, Christian Templin

Registry-linked trialAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Cardiology journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01947621 (International Multicenter Registry on Takotsubo Cardiomyopathy), which is not on this map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01947621 unknown statusnot on this map

International Multicenter Registry on Takotsubo Cardiomyopathy

TypeobservationalSponsorUniversity of ZurichRan2011 to 2020Enrolled4,000ConditionsTakotsubo Cardiomyopathy
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Victoria L CammannUniversity Heart Center, Department of Cardiology, University Hospital Zurich, Switzerland.
Annahita SarconSection of Cardiac Electrophysiology, Department of Medicine, University of California-San Francisco, CA, United States.
Konrad A SzawanUniversity Heart Center, Department of Cardiology, University Hospital Zurich, Switzerland.
Michael WürdingerUniversity Heart Center, Department of Cardiology, University Hospital Zurich, Switzerland.
Saif AzamUniversity of Southern California, Keck School of Medicine, Los Angeles, CA, United States.
Jerold ShinbaneUniversity of Southern California, Keck School of Medicine, Los Angeles, CA, United States.
Burkhardt SeifertDivision of Biostatistics, Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Switzerland.
Jelena R GhadriUniversity Heart Center, Department of Cardiology, University Hospital Zurich, Switzerland.
Jacqueline SawDivision of Cardiology, Vancouver General Hospital, Vancouver, British Columbia, Canada.
Christian TemplinUniversity Heart Center, Department of Cardiology, University Hospital Zurich, Switzerland. christian.templin@usz.ch.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTakotsubo syndrome (TTS) and spontaneous coronary artery dissection (SCAD) are now increasingly recognized. Both conditions predominantly affect females; however, the exact pathophysiology remains unclear. Large multi-center databases can help elucidate the underlying mechanism and optimize treatments to improve outcomes by allowing us to compare features and outcomes of patients with TTS and patients with SCAD.

methodsTakotsubo syndrome patients were enrolled from the International Takotsubo Registry and compared to SCAD patients from the Canadian Spontaneous Coronary Artery Dissection Cohort Study. In total 2098 TTS patients and 750 SCAD patients were included in the present study.

resultsMore than 85% of patients in both groups were females. TTS patients were older compared to SCAD patients. Physical triggers were more common in TTS patients, while emotional triggers and non-identifiable triggering events were more common in SCAD patients. Left ventricular ejection fraction was more impaired in TTS compared to SCAD. TTS patients had more major cardiovascular risk factors, while SCAD patients had a higher rate of migraines and anxiety disorders than TTS patients. Thirty-day mortality was significantly higher in TTS patients, while 30-day stroke rates were comparable between groups.

conclusionsThese findings suggest that women are at higher risk for TTS and SCAD compared to men, which should be considered in the differential diagnosis of those presenting with acute coronary syndrome. Additionally, emotional stressors play a significant role in triggering events particularly in younger women suffering from SCAD. The present findings may help clinicians better differentiate these two entities and aid in the appropriate risk stratification, diagnosis, and management.

trial registrationClinicalTrials.gov no. NCT01947621.

Indexed as

Coronary Vessel AnomaliesStrokeTakotsubo CardiomyopathyVascular DiseasesCanadaCohort StudiesCoronary VesselsFemaleHumansMaleStroke VolumeVentricular Function, Leftspontaneous coronary artery dissectiontakotsubo syndrome

Identifiers

PMID34165180
PMCPMC9987537

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.