ArticleYonsei medical journal2021
Association between Plasma Osmolality and Case Fatality within 1 Year after Severe Acute Ischemic Stroke.
Article in Yonsei medical journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Association of fluid balance with 3-month outcomes in severe acute ischaemic stroke.Stroke and vascular neurology · 2026Article
- Serum Osmolality and Stroke Mortality in the ICU: A U-Shaped Risk Pattern and Its Clinical Implications.Journal of clinical medicine · 2025Article
- The U-shaped relationship between serum osmolality and the risk of sepsis-associated delirium development: a retrospective study.BMC neurology · 2025Article
- Association Between Enhanced Hydration Therapy and Improved Prognosis in Patients With Acute Ischemic Stroke Who Were Treated With Thrombolytics: A Preliminary Study.Emergency medicine international · 2025Article
- The J-shaped relationship between serum osmolality and all-cause mortality in critically ill patients with myocardial infarction: a retrospective cohort study.Frontiers in endocrinology · 2025Article
- Association between osmolality trajectories and mortality in patients with sepsis: a group-based trajectory model in large ICU open access databases.Frontiers in medicine · 2025Article
- Association Between Blood Urea Nitrogen and Delirium in Critically Ill Elderly Patients Without Kidney Diseases: A Retrospective Study and Mendelian Randomization Analysis.CNS neuroscience & therapeutics · 2025Article
- Association between serum osmolality and risk of in-hospital mortality in patients with intracerebral hemorrhage.Frontiers in neurology · 2024Article
- The prevalence of chronic dehydration and associated with cardiometabolic risks among agriculture and aquaculture workers.Frontiers in public health · 2023Article
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Authors and funding
6 authors.
Funding
Abstract
purposePlasma osmolality, a marker of dehydration, is associated with cardiovascular mortality. We aimed to investigate whether elevated plasma osmolality is associated with case fatality within 1 year after severe acute ischemic stroke. MATERIALS AND
methodsWe included severe ischemic stroke patients (defined as National Institutes of Health Stroke Scale ≥15 score) within 24 hours from symptom onset admitted to the Department of Neurology, West China Hospital between January 2017 and June 2019. Admission plasma osmolality was calculated using the equation 1.86*(sodium+potassium)+1.15*glucose+urea+14. Elevated plasma osmolality was defined as plasma osmolality >296 mOsm/kg, indicating a state of dehydration. Study outcomes included 3-month and 1-year case fatalities. Multivariable logistic regression was performed to determine independent associations between plasma osmolality and case fatalities at different time points.
resultsA total of 265 patients with severe acute ischemic stroke were included. The mean age was 71.2±13.1 years, with 51.3% being males. Among the included patients, case fatalities were recorded for 31.7% (84/265) at 3 months and 39.6% (105/265) at 1 year. Elevated plasma osmolality (dehydration) was associated with 3-month case fatality [odds ratio (OR) 1.98, 95% confidence interval (CI) 1.07-3.66,
conclusionElevated plasma osmolality was independently associated with 3-month case fatality, but not 1-year case fatality, for severe acute ischemic stroke.
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