ArticleJournal of biophotonics2021
Intravascular molecular-structural imaging with a miniaturized integrated near-infrared fluorescence and ultrasound catheter.
Article in Journal of biophotonics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- Smart Catheters for Diagnosis, Monitoring, and Therapy.Advanced healthcare materials · 2026Review
- High-Speed Intravascular Near-Infrared Fluorescence-Ultrasound Imaging In Vivo.IEEE transactions on bio-medical engineering · 2026Article
- Optical theranostics in ischemic heart disease: from molecular insights to clinical translation.Theranostics · 2025Review
- Intravascular ICG-enhanced NIRF-IVUS imaging to assess progressive atherosclerotic lesions in excised human coronary arteries.NPJ cardiovascular health · 2024Article
- Accounting for blood attenuation in intravascular near-infrared fluorescence-ultrasound imaging using a fluorophore-coated guidewire.Journal of biomedical optics · 2023Article
- Dual-modality fluorescence lifetime imaging-optical coherence tomography intravascular catheter system with freeform catheter optics.Journal of biomedical optics · 2022Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Coronary artery disease (CAD) remains a leading cause of mortality and warrants new imaging approaches to better guide clinical care. We report on a miniaturized, hybrid intravascular catheter and imaging system for comprehensive coronary artery imaging in vivo. Our catheter exhibits a total diameter of 1.0 mm (3.0 French), equivalent to standalone clinical intravascular ultrasound (IVUS) catheters but enables simultaneous near-infrared fluorescence (NIRF) and IVUS molecular-structural imaging. We demonstrate NIRF-IVUS imaging in vitro in coronary stents using NIR fluorophores, and compare NIRF signal strengths for prism and ball lens sensor designs in both low and high scattering media. Next, in vivo intravascular imaging in pig coronary arteries demonstrates simultaneous, co-registered molecular-structural imaging of experimental CAD inflammation on IVUS and distance-corrected NIRF images. The obtained results suggest substantial potential for the NIRF-IVUS catheter to advance standalone IVUS, and enable comprehensive phenotyping of vascular disease to better assess and treat patients with CAD.
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Registered trials
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