Evidence map›Paper›PMID 34164813›Full record

ArticleImmunology2021

PD-1-induced proliferating T cells exhibit a distinct transcriptional signature.

Marianne Strazza, Shoiab Bukhari, Anna S Tocheva, Adam Mor

Open access · bronzeAbstract read
In one paragraph

Article in Immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Marianne StrazzaColumbia Center for Translational Immunology, Columbia University Medical Center, New York, NY, USA.ORCID 0000-0003-2422-2583
Shoiab BukhariColumbia Center for Translational Immunology, Columbia University Medical Center, New York, NY, USA.
Anna S TochevaColumbia Center for Translational Immunology, Columbia University Medical Center, New York, NY, USA.
Adam MorColumbia Center for Translational Immunology, Columbia University Medical Center, New York, NY, USA.
Columbia University Irving Medical Center · US

Funding

Novel mechanisms regulating PD-1 signaling and functionR01AI125640 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Adam Mor · 2016 to 2026
$4.3M
PAG is a novel target in immunotherapyR01AI150597 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MOR, ADAM · 2020 to 2024
$2.7M
BD Biosciences InfluxS10OD020056 · OD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SNOECK, HANS-WILLEM E · 2015 to 2015
$600k
Becton Dickinson LSR II Analytical Flow CytometerS10RR027050 · NCRR · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CLYNES, RAPHAEL A. · 2011 to 2011
$413k
(PQ8) Predictive biomarkers for the onset of immune-related adverse events associated with PD-1 blockadeR21CA231277 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MOR, ADAM · 2019 to 2020
$361k
NCI NIH HHS R21 CA231277NCRR NIH HHS S10 RR027050NIAID NIH HHS R01 AI125640NIAID NIH HHS R01 AI150597NIH HHS S10 OD020056
6 · The paper itself

Abstract

Ligation of the inhibitory receptor PD-1 on T cells results in the inhibition of numerous cellular functions. Despite the overtly inhibitory outcome of PD-1 signalling, there are additionally a collection of functions that are activated. We have observed that CD4

Indexed as

CD4-Positive T-LymphocytesCell ProliferationCells, CulturedDatasets as TopicHumansImmunophenotypingLymphocyte ActivationPrimary Cell CultureProgrammed Cell Death 1 ReceptorReceptors, Antigen, T-CellRNA-SeqSingle-Cell AnalysisT-Lymphocyte SubsetsTranscriptomePDCD1 protein, humanProgrammed Cell Death 1 ReceptorReceptors, Antigen, T-CellPD-1proliferationRNA sequencingT cells

Identifiers

PMID34164813
PMCPMC8517598
OpenAlexW3174714938

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.