ArticleJournal of cell science2021
me31B regulates stem cell homeostasis by preventing excess dedifferentiation in the Drosophila male germline.
Article in Journal of cell science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 13 citations in OpenAlex.
- Niche-dependent modular regulation of the stem cell transcriptome separates cell identity and potential.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Me31B: a key repressor in germline regulation and beyond.Bioscience reports · 2024Review
- P-body-like condensates in the germline.Seminars in cell & developmental biology · 2024Review
- Review
- Review
- Specialized germline P-bodies are required to specify germ cell fate in Caenorhabditis elegans embryos.Development (Cambridge, England) · 2022Article
- Endoplasmic reticulum-associated protein degradation contributes to Toll innate immune defense inFrontiers in immunology · 2022Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Tissue-specific stem cells maintain tissue homeostasis by providing a continuous supply of differentiated cells throughout the life of organisms. Differentiated/differentiating cells can revert back to a stem cell identity via dedifferentiation to help maintain the stem cell pool beyond the lifetime of individual stem cells. Although dedifferentiation is important for maintaining the stem cell population, it is speculated that it underlies tumorigenesis. Therefore, this process must be tightly controlled. Here, we show that a translational regulator, me31B, plays a critical role in preventing excess dedifferentiation in the Drosophila male germline: in the absence of me31B, spermatogonia dedifferentiate into germline stem cells (GSCs) at a dramatically elevated frequency. Our results show that the excess dedifferentiation is likely due to misregulation of nos, a key regulator of germ cell identity and GSC maintenance. Taken together, our data reveal negative regulation of dedifferentiation to balance stem cell maintenance with differentiation.
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Registered trials
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