Evidence map›Paper›PMID 34164626›Full record

ArticleBlood cancer discovery2021

Dissecting Clonal Hematopoiesis in Tissues of Classical Hodgkin Lymphoma Patients.

Alessandra Venanzi, Andrea Marra, Gianluca Schiavoni, Sara G Milner, Roberto Limongello, Alessia Santi, Valentina Pettirossi, Simona Ultimo, Luisa Tasselli, Alessandra Pucciarini and 7 more

Open access · greenAbstract read
In one paragraph

Article in Blood cancer discovery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 32 citations in OpenAlex.

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  12. Genetic lesions and targeted therapy in Hodgkin lymphoma.Therapeutic advances in hematology · 2023
    Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Review
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  19. Clonal Hematopoiesis: Role in Hematologic and Non-Hematologic Malignancies.Mediterranean journal of hematology and infectious diseases · 2022
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 1 institution in 1 country.

Alessandra Venanzi *Institute of Hematology and Center for Hemato-Oncology Research, University and Hospital of Perugia, Perugia, Italy.
Andrea Marra *Institute of Hematology and Center for Hemato-Oncology Research, University and Hospital of Perugia, Perugia, Italy.ORCID 0000-0002-4724-9327
Gianluca Schiavoni *Institute of Hematology and Center for Hemato-Oncology Research, University and Hospital of Perugia, Perugia, Italy.
Sara G MilnerInstitute of Hematology and Center for Hemato-Oncology Research, University and Hospital of Perugia, Perugia, Italy.
Roberto LimongelloInstitute of Hematology and Center for Hemato-Oncology Research, University and Hospital of Perugia, Perugia, Italy.
Alessia SantiInstitute of Hematology and Center for Hemato-Oncology Research, University and Hospital of Perugia, Perugia, Italy.
Valentina PettirossiInstitute of Hematology and Center for Hemato-Oncology Research, University and Hospital of Perugia, Perugia, Italy.
Simona UltimoInstitute of Hematology and Center for Hemato-Oncology Research, University and Hospital of Perugia, Perugia, Italy.
Luisa TasselliInstitute of Hematology and Center for Hemato-Oncology Research, University and Hospital of Perugia, Perugia, Italy.ORCID 0000-0003-3349-1371
Alessandra PucciariniInstitute of Hematology and Center for Hemato-Oncology Research, University and Hospital of Perugia, Perugia, Italy.
Lorenza FaliniInstitute of Hematology and Center for Hemato-Oncology Research, University and Hospital of Perugia, Perugia, Italy.ORCID 0000-0001-6194-9867
Sofia SciabolacciInstitute of Hematology and Center for Hemato-Oncology Research, University and Hospital of Perugia, Perugia, Italy.
Maria Paola MartelliInstitute of Hematology and Center for Hemato-Oncology Research, University and Hospital of Perugia, Perugia, Italy.ORCID 0000-0001-9139-1729
Paolo SportolettiInstitute of Hematology and Center for Hemato-Oncology Research, University and Hospital of Perugia, Perugia, Italy.
Stefano AscaniInstitute of Hematology and Center for Hemato-Oncology Research, University and Hospital of Perugia, Perugia, Italy.
Brunangelo Falini *Institute of Hematology and Center for Hemato-Oncology Research, University and Hospital of Perugia, Perugia, Italy. enrico.tiacci@unipg.it brunangelo.falini@unipg.it.ORCID 0000-0001-6194-9867
Enrico Tiacci *Institute of Hematology and Center for Hemato-Oncology Research, University and Hospital of Perugia, Perugia, Italy. enrico.tiacci@unipg.it brunangelo.falini@unipg.it.
University of Perugia · IT

Funding

European Research Council 740230
6 · The paper itself

Abstract

Clonal hematopoiesis predisposes to hematological malignancies. However, clonal hematopoiesis is understudied in classical Hodgkin lymphoma (cHL), a mature B-cell neoplasm exhibiting the most abundant microenvironment. We analyzed clonal hematopoiesis in 40 cHL cases by sequencing microdissected tumor cells and matched normal cells from blood and/or lymph nodes. Five patients had blood and/or tissue clonal hematopoiesis. In three of five patients (all failing first-line therapy), clonal hematopoiesis spread through the tissue microenvironment extensively, and featured mutant

Indexed as

Epstein-Barr Virus InfectionsHodgkin DiseaseClonal HematopoiesisHerpesvirus 4, HumanHumansMutationTumor MicroenvironmentAcute myeloid leukemiaClonal hematopoiesisDNMT3AHodgkin lymphomaMicroenvironmentNPM1

Identifiers

PMID34164626
PMCPMC7611041
OpenAlexW3154807347

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.