Evidence map›Paper›PMID 34164548›Full record

ArticleAnnals of translational medicine2021

Matched pair analysis to evaluate weight loss during radiation therapy for head and neck cancer as a prognostic factor for survival.

Hye Ri Han, Gregory M Hermann, Sung Jun Ma, Austin J Iovoli, Kimberly E Wooten, Hassan Arshad, Vishal Gupta, Ryan P McSpadden, Moni A Kuriakose, Michael R Markiewicz and 6 more

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Article in Annals of translational medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
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  5. Review
4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Hye Ri HanJacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, New York, NY, USA.
Gregory M HermannDepartment of Radiation Medicine, Roswell Park Comprehensive Cancer Center, New York, NY, USA.
Sung Jun MaDepartment of Radiation Medicine, Roswell Park Comprehensive Cancer Center, New York, NY, USA.
Austin J IovoliDepartment of Radiation Medicine, Roswell Park Comprehensive Cancer Center, New York, NY, USA.
Kimberly E WootenDepartment of Head and Neck Surgery, Roswell Park Comprehensive Cancer Center, New York, NY, USA.
Hassan ArshadDepartment of Head and Neck Surgery, Roswell Park Comprehensive Cancer Center, New York, NY, USA.
Vishal GuptaDepartment of Head and Neck Surgery, Roswell Park Comprehensive Cancer Center, New York, NY, USA.
Ryan P McSpaddenDepartment of Head and Neck Surgery, Roswell Park Comprehensive Cancer Center, New York, NY, USA.
Moni A KuriakoseDepartment of Head and Neck Surgery, Roswell Park Comprehensive Cancer Center, New York, NY, USA.
Michael R MarkiewiczDepartment of Head and Neck Surgery, Roswell Park Comprehensive Cancer Center, New York, NY, USA.
Jon M ChanDepartment of Head and Neck Surgery, Roswell Park Comprehensive Cancer Center, New York, NY, USA.
Mary E PlatekDepartment of Radiation Medicine, Roswell Park Comprehensive Cancer Center, New York, NY, USA.
Andrew D RayDepartment of Cancer Prevention and Control, Roswell Park Comprehensive Cancer Center, New York, NY, USA.
Fangyi GuDepartment of Cancer Prevention and Control, Roswell Park Comprehensive Cancer Center, New York, NY, USA.
Wesley L HicksDepartment of Head and Neck Surgery, Roswell Park Comprehensive Cancer Center, New York, NY, USA.
Anurag K SinghDepartment of Radiation Medicine, Roswell Park Comprehensive Cancer Center, New York, NY, USA.

Funding

Two-Spirit Films in Indigenous Cancer HealthP30CA016056 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI Dean G. Tang · 1985 to 2026
$116.6M
NCI NIH HHS P30 CA016056
6 · The paper itself

Abstract

backgroundOne frequent consequence of radiation therapy (RT) for head and neck cancer (HNC) is weight loss (WL). HNC patients reportedly lose about 9% of their weight during treatment, regardless of pre-treatment WL and nutritional support. We investigated whether high WL during RT has an association with overall (OS) and cancer-specific survival (CSS).

methodsWe retrospectively reviewed weight during RT in HNC patients treated at Roswell Park Comprehensive Cancer Center between 2003 and 2017. High WL was defined as greater than or equal to the median WL. Logistic regression analysis was performed to identify predictors for WL during RT. Multivariate Cox regression and Kaplan-Meier analyses were used to estimate survival outcomes. Propensity score matching was performed to obtain balanced matched-pairs and compare survival outcomes.

resultsA total of 843 patients received either definitive (71%) or post-operative (29%) RT. Median follow-up was 53.6 months [interquartile range (IQR) 35.7-88.9]. Median WL was 5.8% (IQR 0.24-10.6) from baseline weight. Patients with high WL had better OS [hazard ratio (HR) 0.75, 95% confidence interval (CI), 0.61-0.93, P=0.01] and CSS (HR 0.71, 95% CI, 0.55-0.93, P=0.01). 258 matched-pairs were analyzed. Median follow-up was 54.8 months (IQR 35.8-90.4). Median OS was 39.2 months (IQR 21.4-75.7) for high WL versus 36.7 months (IQR 14.6-61.7) for low WL cohorts (P=0.047).

conclusionsDifferent from previous reports, this study shows that patients with less WL have worse OS. WL during RT may not be a reliable marker for worse prognosis. A better way to evaluate malnutrition in patients undergoing RT is warranted.

Indexed as

cancer specific survivalHead and neck cancer (HNC)overall survival (OS)radiotherapyweight loss (WL)

Identifiers

PMID34164548
PMCPMC8184423

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.