ArticleFrontiers in cell and developmental biology2021
Salamander Insights Into Ageing and Rejuvenation.
Article in Frontiers in cell and developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Cell-type Plasticity Supports Behavioral Adaptations at the Water-to-Land Interface.bioRxiv : the preprint server for biology · 2026Article
- The adrenal stress response involves distinct dynamics of both cortisol and corticosterone in the axolotl salamander.Lab animal · 2026Article
- Molecular evolution of animal aging.The EMBO journal · 2026Review
- Axolotls retain fertility throughout lifespan.BMC biology · 2026Article
- The Multifaceted Importance of Amphibians: Ecological, Biomedical, and Socio-Economic Perspectives.Biology · 2026Review
- The evolution of cancer and ageing: a history of constraint.Nature reviews. Cancer · 2025Review
- Retrotransposon Expression Is Upregulated in Adulthood and Suppressed during Regeneration of the Limb in the Axolotl (Ambystoma mexicanum).Advanced biology · 2025Article
- Biomarkers of aging: from molecules and surrogates to physiology and function.Physiological reviews · 2025Review
- Investigating Neotenic and Metamorphic Axolotl Brain Complexity: A Stereological and Immunohistochemical Perspective.The Journal of comparative neurology · 2025Article
- Emerging insights in senescence: pathways from preclinical models to therapeutic innovations.npj aging · 2024Review
- Genomic Gigantism is not Associated with Reduced Selection Efficiency in Neotropical Salamanders.Journal of molecular evolution · 2024Article
- Molecular Signatures Integral to Natural Reprogramming in the Pigment Epithelium Cells after Retinal Detachment inInternational journal of molecular sciences · 2023Article
- Evolutionary Insights into the Relationship of Frogs, Salamanders, and Caecilians and Their Adaptive Traits, with an Emphasis on Salamander Regeneration and Longevity.Animals : an open access journal from MDPI · 2023Article
- Review
- Construction of the axolotl cell landscape using combinatorial hybridization sequencing at single-cell resolution.Nature communications · 2022Article
- Editorial: Mechanisms and Pathways Contributing to the Diversity of Aging Across the Tree of Life.Frontiers in cell and developmental biology · 2022Article
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Exhibiting extreme regenerative abilities which extend to complex organs and entire limbs, salamanders have long served as research models for understanding the basis of vertebrate regeneration. Yet these organisms display additional noteworthy traits, namely extraordinary longevity, indefinite regenerative potential and apparent lack of traditional signs of age-related decay or "negligible senescence." Here, I examine existing studies addressing these features, highlight outstanding questions, and argue that salamanders constitute valuable models for addressing the nature of organismal senescence and the interplay between regeneration and ageing.
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Registered trials
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