Evidence map›Paper›PMID 34164347›Full record

ArticleFrontiers in cellular and infection microbiology2021

Risk of Environmental Exposure to H7N9 Influenza Virus

Cheng Zhang, Kangkang Guo, Huan Cui, Ligong Chen, Chunmao Zhang, Xuejing Wang, Jiaming Li, Yingying Fu, Zhongyi Wang, Zhendong Guo and 2 more

Abstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Viruses · 2026
    Article
  3. Article
  4. Article
  5. Avian influenza overview March-June 2025.EFSA journal. European Food Safety Authority · 2025
    Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Cheng ZhangCollege of Veterinary Medicine, Hebei Agricultural University, Baoding, China.
Kangkang GuoCollege of Veterinary Medicine, Hebei Agricultural University, Baoding, China.
Huan CuiChangchun Veterinary Research Institute, Chinese Academy of Agriculture Sciences, Changchun, China.
Ligong ChenCollege of Veterinary Medicine, Hebei Agricultural University, Baoding, China.
Chunmao ZhangChangchun Veterinary Research Institute, Chinese Academy of Agriculture Sciences, Changchun, China.
Xuejing WangCollege of Veterinary Medicine, Hebei Agricultural University, Baoding, China.
Jiaming LiBeijing Institute of Biotechnology, Beijing, China.
Yingying FuBeijing Institute of Biotechnology, Beijing, China.
Zhongyi WangBeijing Institute of Biotechnology, Beijing, China.
Zhendong GuoChangchun Veterinary Research Institute, Chinese Academy of Agriculture Sciences, Changchun, China.
Juxiang LiuCollege of Veterinary Medicine, Hebei Agricultural University, Baoding, China.
Shishan DongCollege of Veterinary Medicine, Hebei Agricultural University, Baoding, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Environmental transmission of viruses to humans has become an early warning for potential epidemic outbreaks, such as SARS-CoV-2 and influenza virus outbreaks. Recently, an H7N9 virus, A/environment/Hebei/621/2019 (H7N9), was isolated by environmental swabs from a live poultry market in Hebei, China. We found that this isolate could be transmitted by direct contact and aerosol in mammals. More importantly, after 5 passages in mice, the virus acquired two adaptive mutations, PB1-H115Q and B2-E627K, exhibiting increased virulence and aerosol transmissibility. These results suggest that this H7N9 virus might potentially be transmitted between humans through environmental or airborne routes.

Indexed as

Environmental ExposureInfluenza A Virus, H7N9 SubtypeInfluenza, HumanInfluenza in BirdsAnimalsChinaHumansMicePoultryenvironmental and airborne transmissibilityH7N9 virushuman exposure riskmammalian adaptionpathogenicity

Identifiers

PMID34164347
PMCPMC8216215

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.