Evidence map›Paper›PMID 34164154›Full record

ArticleReaction chemistry & engineering2020

Green and efficient synthesis of the radiopharmaceutical [

Jia Wang, Travis Holloway, Ksenia Lisova, R Michael van Dam

Abstract read
In one paragraph

Article in Reaction chemistry & engineering, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Detrimental impact of aqueous mobile phases on 18F-labelled radiopharmaceutical analysisAnalytical methods : advancing methods and applications · 2023
    Article
  5. Article
  6. Article
  7. Article
  8. Optimization of Radiochemical Reactions using Droplet Arrays.Journal of visualized experiments : JoVE · 2021
    Article
  9. Article
  10. Nucleophilic Synthesis of 6-l-[Molecules (Basel, Switzerland) · 2020
    Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jia WangDepartment of Bioengineering, Henry Samueli School of Engineering.
Travis HollowayDepartment of Molecular and Medical Pharmacology, David Geffen School of Medicine.
Ksenia LisovaDepartment of Molecular and Medical Pharmacology, David Geffen School of Medicine.
R Michael van DamDepartment of Bioengineering, Henry Samueli School of Engineering.

Funding

Research Training in Biomedical PhysicsT32EB002101 · NIBIB · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Michael F McNitt-Gray · 2003 to 2026
$5.3M
Commercialization of a Benchtop Radiosynthesizer for the Production of PET ProbesR44MH097271 · NIMH · SOFIE BIOSCIENCES, INC. · PI MOORE, MELISSA · 2013 to 2018
$3.8M
Optimization and validation of integrated microscale technologies for low-cost, automated production of PET molecular imaging tracers for cancer researchR33CA240201 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI VAN DAM, ROBERT MICHAEL · 2019 to 2021
$1.1M
Automated microfluidic production of high specific activity PET tracers to enable routine CNS imagingR21AG049918 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI VAN DAM, ROBERT MICHAEL · 2015 to 2017
$693k
High-throughput radiochemistry platform for accelerated discovery and development of novel PET imaging agents for cancerR21CA212718 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI VAN DAM, ROBERT MICHAEL · 2017 to 2018
$616k
NCI NIH HHS R21 CA212718NCI NIH HHS R33 CA240201NIA NIH HHS R21 AG049918NIBIB NIH HHS T32 EB002101NIMH NIH HHS R44 MH097271
6 · The paper itself

Abstract

From an efficiency standpoint, microdroplet reactors enable significant improvements in the preparation of radiopharmaceuticals due to the vastly reduced reaction volume. To demonstrate these advantages, we adapt the conventional (macroscale) synthesis of the clinically-important positron-emission tomography tracer [

Indexed as

Green chemistryMicrodroplet reactorMicrofluidicsPositron emission tomographyRadiochemistry

Identifiers

PMID34164154
PMCPMC8218909

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.